Scamp1 secretory carrier membrane protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Scamp1provided by MGI
Official Full Name: secretory carrier membrane protein 1provided by MGI
Primary source: MGI:MGI:1349480
See related: Ensembl:ENSMUSG00000021687 AllianceGenome:MGI:1349480
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4930505M11Rik
Summary: Predicted to enable protein domain specific binding activity. Acts upstream of or within establishment of localization in cell and exocytosis. Located in synaptic vesicle membrane and zymogen granule membrane. Is expressed in neural retinal epithelium; retina inner nuclear layer; retina nuclear layer; and retina outer nuclear layer. Orthologous to human SCAMP1 (secretory carrier membrane protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in frontal lobe adult (RPKM 34.4), CNS E18 (RPKM 30.4) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 C3; 13 49.22 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (94337818..94422339, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (94201310..94285831, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI415563 (e-PCR)
- UniSTS:160327

AW122395 (e-PCR)
- UniSTS:180578

MHAa27d4.seq (e-PCR)
- UniSTS:125104

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in endocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	ISO Inferred from Sequence Orthology more info
involved_in protein transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in clathrin-coated vesicle	IEA Inferred from Electronic Annotation more info
located_in clathrin-coated vesicle	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in recycling endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in recycling endosome membrane	ISO Inferred from Sequence Orthology more info
located_in recycling endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle	TAS Traceable Author Statement more info	PubMed
located_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	ISS Inferred from Sequence or Structural Similarity more info
is_active_in trans-Golgi network membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in zymogen granule membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: secretory carrier-associated membrane protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001346609.1 → NP_001333538.1 secretory carrier-associated membrane protein 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC148334, AK135058, AK162168

Consensus CDS

CCDS84049.1

UniProtKB/TrEMBL

Q3TSA8, Q9D577

Related

ENSMUSP00000123135.2, ENSMUST00000152555.8

Conserved Domains (2) summary

pfam04144
Location:65 → 240

SCAMP; SCAMP family

cl03075
Location:13 → 63

GrpE; nucleotide exchange factor GrpE
NM_029153.1 → NP_083429.1 secretory carrier-associated membrane protein 1 isoform 1

See identical proteins and their annotated locations for NP_083429.1

Status: VALIDATED

Source sequence(s)

BC034283

Consensus CDS

CCDS36750.1

UniProtKB/Swiss-Prot

Q8K021

UniProtKB/TrEMBL

Q3TD71, Q3UY11

Related

ENSMUSP00000022197.9, ENSMUST00000022197.15

Conserved Domains (1) summary

pfam04144
Location:117 → 292

SCAMP; SCAMP family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

94337818..94422339 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030247117.1 → XP_030102977.1 secretory carrier-associated membrane protein 1 isoform X1

UniProtKB/TrEMBL

Q3TSA8, Q9D577

Conserved Domains (2) summary

pfam04144
Location:65 → 240

SCAMP; SCAMP family

cl03075
Location:13 → 63

GrpE; nucleotide exchange factor GrpE
XM_030247116.1 → XP_030102976.1 secretory carrier-associated membrane protein 1 isoform X1

UniProtKB/TrEMBL

Q3TSA8, Q9D577

Conserved Domains (2) summary

pfam04144
Location:65 → 240

SCAMP; SCAMP family

cl03075
Location:13 → 63

GrpE; nucleotide exchange factor GrpE
XM_006517515.3 → XP_006517578.1 secretory carrier-associated membrane protein 1 isoform X1

See identical proteins and their annotated locations for XP_006517578.1

UniProtKB/TrEMBL

Q3TSA8, Q9D577

Related

ENSMUSP00000120053.2, ENSMUST00000153558.8

Conserved Domains (2) summary

pfam04144
Location:65 → 240

SCAMP; SCAMP family

cl03075
Location:13 → 63

GrpE; nucleotide exchange factor GrpE