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    Tkfc triokinase, FMN cyclase [ Mus musculus (house mouse) ]

    Gene ID: 225913, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tkfcprovided by MGI
    Official Full Name
    triokinase, FMN cyclaseprovided by MGI
    Primary source
    MGI:MGI:2385084
    See related
    Ensembl:ENSMUSG00000034371 AllianceGenome:MGI:2385084
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dak
    Summary
    Enables triokinase activity. Involved in fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate. Predicted to be active in cytosol. Orthologous to human TKFC (triokinase and FMN cyclase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver adult (RPKM 116.1), kidney adult (RPKM 103.3) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tkfc in Genome Data Viewer
    Location:
    19 A; 19 6.6 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (10565153..10583257, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (10592197..10605482, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene cleavage and polyadenylation specific factor 7 Neighboring gene transmembrane protein 216 Neighboring gene STARR-positive B cell enhancer ABC_E9455 Neighboring gene transmembrane protein 138 Neighboring gene cytochrome b561 family, member A3 Neighboring gene STARR-positive B cell enhancer ABC_E5687 Neighboring gene damage specific DNA binding protein 1 Neighboring gene RIKEN cDNA 4930524O05 gene Neighboring gene von Willebrand factor C and EGF domains Neighboring gene STARR-seq mESC enhancer starr_45554 Neighboring gene pepsinogen 5, group I

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Enzymes of glycerol and glyceraldehyde metabolism in mouse liver: effects of caloric restriction and age on activities. Hagopian K, et al. Biosci Rep, 2008 Apr. PMID 18429748, Free PMC Article
    2. The TKFC Ala185Thr variant, reported as 'null' for fructose metabolism, is fully active as triokinase. Ribeiro JM, et al. FEBS Lett, 2022 Jun. PMID 35114011
    3. Triose Kinase Controls the Lipogenic Potential of Fructose and Dietary Tolerance. Liu L, et al. Cell Metab, 2020 Oct 6. PMID 32818435
    4. Identification of the glycogenic compound 5-iodotubercidin as a general protein kinase inhibitor. Massillon D, et al. Biochem J, 1994 Apr 1. PMID 8166629, Free PMC Article
    5. HNF4α is required for Tkfc promoter activation by ChREBP. Tsukamoto R, et al. Biosci Biotechnol Biochem, 2024 Jul 22. PMID 38782732

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HNF4alpha is required for Tkfc promoter activation by ChREBP.
      Title: HNF4α is required for Tkfc promoter activation by ChREBP.
    2. The TKFC Ala185Thr variant, reported as 'null' for fructose metabolism, is fully active as triokinase.
      Title: The TKFC Ala185Thr variant, reported as 'null' for fructose metabolism, is fully active as triokinase.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2)  1 citation
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC28742

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FAD-AMP lyase (cyclizing) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FAD-AMP lyase (cyclizing) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycerone kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycerone kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerone kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables triokinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables triokinase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in carbohydrate phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carbohydrate phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycerol catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycerol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within glycolytic process through fructose-1-phosphate IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in negative regulation of MDA-5 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of MDA-5 signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    triokinase/FMN cyclase
    Names
    bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)
    dihydroxyacetone kinase 2 homolog
    NP_001404794.1
    NP_001404795.1
    NP_001404796.1
    NP_001404798.1
    NP_001404799.1
    NP_001404800.1
    NP_663471.1
    XP_006527004.1
    XP_011245525.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417865.1 → NP_001404794.1  triokinase/FMN cyclase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125093
      UniProtKB/Swiss-Prot
      Q8VC30
      Related
      ENSMUSP00000157520.2, ENSMUST00000236607.2

    2. NM_001417866.1 → NP_001404795.1  triokinase/FMN cyclase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125093
      UniProtKB/Swiss-Prot
      Q8VC30

    3. NM_001417867.1 → NP_001404796.1  triokinase/FMN cyclase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125093
      UniProtKB/Swiss-Prot
      Q8VC30
      Related
      ENSMUSP00000158068.2, ENSMUST00000236950.2

    4. NM_001417869.1 → NP_001404798.1  triokinase/FMN cyclase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125093
      UniProtKB/TrEMBL
      Q3UTZ4
      Related
      ENSMUSP00000158115.2, ENSMUST00000237788.2

    5. NM_001417870.1 → NP_001404799.1  triokinase/FMN cyclase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125093
      UniProtKB/TrEMBL
      Q3UTZ4

    6. NM_001417871.1 → NP_001404800.1  triokinase/FMN cyclase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125093
      UniProtKB/TrEMBL
      Q3UTZ4

    7. NM_145496.2 → NP_663471.1  triokinase/FMN cyclase isoform 1

      See identical proteins and their annotated locations for NP_663471.1

      Status: VALIDATED

      Source sequence(s)
      AC125093
      Consensus CDS
      CCDS37914.1
      UniProtKB/Swiss-Prot
      Q8VC30
      Related
      ENSMUSP00000044556.7, ENSMUST00000037678.7
      Conserved Domains (1) summary
      cl29418
      Location:4 → 570
      Dak2; DAK2 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      10565153..10583257 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526941.5 → XP_006527004.1  triokinase/FMN cyclase isoform X1

      Conserved Domains (1) summary
      cl29418
      Location:56 → 622
      Dak2; DAK2 domain

    2. XM_011247223.3 → XP_011245525.1  triokinase/FMN cyclase isoform X3

      Conserved Domains (1) summary
      cl29418
      Location:2 → 565
      Dak2; DAK2 domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VC30.1 GenPept UniProtKB/Swiss-Prot:Q8VC30

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