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    Nfs1 Nfs1 cysteine desulfurase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34613, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nfs1provided by FlyBase
    Official Full Name
    Nfs1 cysteine desulfuraseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032393
    Locus tag
    Dmel_CG12264
    See related
    AllianceGenome:FB:FBgn0032393
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12264; CG12264-PA; CSE; Dmel\CG12264; DmNfs1; NFS1
    Summary
    Enables cysteine desulfurase activity. Involved in iron-sulfur cluster assembly. Located in cytosol and nucleus. Part of mitochondrial [2Fe-2S] assembly complex. Is expressed in adult head; adult heart; embryonic/larval midgut; larval visceral muscle cell; and organism. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 52. Orthologous to human NFS1 (NFS1 cysteine desulfurase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nfs1 in Genome Data Viewer
    Location:
    33B5-33B5; 2-45 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (11999654..12001244)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (11999654..12001244)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Quetzalcoatl Neighboring gene transcriptional Adaptor 1-1 Neighboring gene uncharacterized protein Neighboring gene 3-hydroxyacyl-CoA dehydratase 1 Neighboring gene Rhodopsin 5 Neighboring gene long non-coding RNA:CR44588

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpression of CBS and CSE genes affects lifespan, stress resistance and locomotor activity in Drosophila melanogaster. Shaposhnikov M, et al. Aging (Albany NY), 2018 Nov 8. PMID 30408770, Free PMC Article
    2. Effects of N-acetyl-L-cysteine on lifespan, locomotor activity and stress-resistance of 3 Drosophila species with different lifespans. Shaposhnikov MV, et al. Aging (Albany NY), 2018 Sep 20. PMID 30243020, Free PMC Article
    3. The one-carbon pool controls mitochondrial energy metabolism via complex I and iron-sulfur clusters. Rosenberger FA, et al. Sci Adv, 2021 Feb. PMID 33608280, Free PMC Article
    4. A defect in mitochondrial fatty acid synthesis impairs iron metabolism and causes elevated ceramide levels. Dutta D, et al. Nat Metab, 2023 Sep. PMID 37653044, Free PMC Article
    5. Adaptive impact of the chimeric gene Quetzalcoatl in Drosophila melanogaster. Rogers RL, et al. Proc Natl Acad Sci U S A, 2010 Jun 15. PMID 20534482, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cysteine desulfurase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine desulfurase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine desulfurase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine desulfurase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in [2Fe-2S] cluster assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in iron-sulfur cluster assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in iron-sulfur cluster assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in iron-sulfur cluster assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrial tRNA thio-modification ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mitochondrial [2Fe-2S] assembly complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in mitochondrial matrix IC
    Inferred by Curator
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Nfs1 cysteine desulfurase
    Names
    CG12264-PA
    IscS homologue
    Nfs1-PA
    NP_609533.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      11999654..12001244
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135689.2 → NP_609533.1  Nfs1 cysteine desulfurase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609533.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VKD3, Q9VKD4
      Related
      FBpp0079874, FBtr0080290
      Conserved Domains (1) summary
      cl18945
      Location:63 → 462
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VKD3.1 Q9VKD3

    Gene LinkOut

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