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    vlc vulcan [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 46078, updated on 9-Dec-2024

    Summary

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    Official Symbol
    vlcprovided by FlyBase
    Official Full Name
    vulcanprovided by FlyBase
    Primary source
    FLYBASE:FBgn0259978
    Locus tag
    Dmel_CG8390
    See related
    AllianceGenome:FB:FBgn0259978
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-41Fa; anon-WO0118547.98; CG8390; Dmel\CG8390; l(2)07022; X
    Summary
    Predicted to enable molecular adaptor activity. Predicted to be involved in modulation of chemical synaptic transmission. Predicted to be active in glutamatergic synapse and postsynaptic specialization. Is expressed in cephalic furrow; organism; and ventral furrow. Orthologous to several human genes including DLGAP1 (DLG associated protein 1); DLGAP2 (DLG associated protein 2); and DLGAP3 (DLG associated protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See vlc in Genome Data Viewer
    Location:
    41F8-41F8; 2-55 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (5702112..5705439)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (1589617..1592944)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene scarface Neighboring gene Cytosolic non-specific dipeptidase 2 Neighboring gene apterous Neighboring gene lethal (2) 09851

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. [Analysis of the chromocenter DNA composition in polytene chromosomes of Drosophila orena ovarian nurse cells]. Usov KE, et al. Genetika, 2011 Apr. PMID 21675236
    2. Origin and evolution of a new retained intron on the vulcan gene in Drosophila melanogaster subgroup species. Zhan L, et al. Genome, 2014 Oct. PMID 25723758
    3. Apterous is a Drosophila LIM domain gene required for the development of a subset of embryonic muscles. Bourgouin C, et al. Neuron, 1992 Sep. PMID 1524829
    4. An enhancer trap screen for ecdysone-inducible genes required for Drosophila adult leg morphogenesis. Gates J, et al. Genetics, 2000 Dec. PMID 11102372, Free PMC Article
    5. The Drosophila melanogaster Mutants apblot and apXasta Affect an Essential apterous Wing Enhancer. Bieli D, et al. G3 (Bethesda), 2015 Apr 2. PMID 25840432, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A newly created intron (Intron L) was identified on exon 2 of vulcan in D. melanogaster.
      Title: Origin and evolution of a new retained intron on the vulcan gene in Drosophila melanogaster subgroup species.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in glutamatergic synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic specialization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    vulcan
    Names
    CG8390-PA
    CG8390-PB
    CG8390-PC
    CG8390-PE
    CG8390-PF
    CG8390-PG
    CG8390-PH
    CG8390-PI
    anon-41Fa
    transcription unit X
    vlc-PA
    vlc-PB
    vlc-PC
    vlc-PE
    vlc-PF
    vlc-PG
    vlc-PH
    vlc-PI

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      5702112..5705439
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001169585.3 → NP_001163056.1  vulcan, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163056.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z6H3, Q7K1T1
      Conserved Domains (1) summary
      pfam03359
      Location:246 → 575
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    2. NM_080129.5 → NP_524868.1  vulcan, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524868.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z6H3, Q7K1T1
      Related
      FBpp0085375
      Conserved Domains (1) summary
      pfam03359
      Location:246 → 575
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    3. NM_165442.5 → NP_724425.1  vulcan, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724425.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z6H3, Q7K1T1
      Related
      FBpp0085377
      Conserved Domains (1) summary
      pfam03359
      Location:246 → 575
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    4. NM_165444.5 → NP_724427.1  vulcan, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724427.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z6H4
      Related
      FBpp0085376
      Conserved Domains (1) summary
      pfam03359
      Location:224 → 553
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    5. NM_165443.4 → NP_724426.3  vulcan, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724426.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z6H3, Q7K1T1
      Conserved Domains (1) summary
      pfam03359
      Location:246 → 575
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    6. NM_001259214.2 → NP_001246143.1  vulcan, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246143.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z6H3, Q7K1T1
      Conserved Domains (1) summary
      pfam03359
      Location:246 → 575
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    7. NM_001169586.1 → NP_001163057.1  vulcan, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163057.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z6H3, Q7K1T1
      Conserved Domains (1) summary
      pfam03359
      Location:246 → 575
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    8. NM_001259213.1 → NP_001246142.1  vulcan, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246142.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z6H3, Q7K1T1
      Conserved Domains (1) summary
      pfam03359
      Location:246 → 575
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z6H4 A1Z6H4
    Q7K1T1 Q7K1T1

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