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    CG8560 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38830, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG8560provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035781
    Locus tag
    Dmel_CG8560
    See related
    AllianceGenome:FB:FBgn0035781
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CT14378; Dmel\CG8560
    Summary
    Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Is expressed in adult head; dorsal sensory complex proper primordium; embryonic proventriculus; and embryonic/larval midgut. Human ortholog(s) of this gene implicated in familial febrile seizures 11 and familial temporal lobe epilepsy 5. Orthologous to human CPA6 (carboxypeptidase A6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8560 in Genome Data Viewer
    Location:
    65F11-65F11; 3-20 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7402332..7404181, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7395432..7397281, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR33948 Neighboring gene long non-coding RNA:CR44525

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Buffering and proteolysis are induced by segmental monosomy in Drosophila melanogaster. Lundberg LE, et al. Nucleic Acids Res, 2012 Jul. PMID 22434883, Free PMC Article
    2. Introgression in the Drosophila subobscura--D. Madeirensis sister species: evidence of gene flow in nuclear genes despite mitochondrial differentiation. Herrig DK, et al. Evolution, 2014 Mar. PMID 24152112, Free PMC Article
    3. Genomic response to selection for postponed senescence in Drosophila. Wilson RH, et al. Mech Ageing Dev, 2013 Mar. PMID 23262286, Free PMC Article
    4. New comparative genomics approach reveals a conserved health span signature across species. Antosh M, et al. Aging (Albany NY), 2011 Jun. PMID 21775776, Free PMC Article
    5. Single-cell transcriptome characteristics of testicular terminal epithelium lineages during aging in the Drosophila. Chen X, et al. Aging Cell, 2024 Mar. PMID 38044573, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metallocarboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallocarboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8560-PA
    CG8560-PB
    NP_001261516.1
    NP_648120.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      7402332..7404181 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139863.4 → NP_648120.3  uncharacterized protein Dmel_CG8560, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648120.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q961J8, Q9VS68
      Related
      FBpp0076578
      Conserved Domains (2) summary
      cd03860
      Location:123 → 414
      M14_CP_A-B_like; Peptidase M14 carboxypeptidase subfamily A/B-like
      pfam02244
      Location:29 → 98
      Propep_M14; Carboxypeptidase activation peptide

    2. NM_001274587.1 → NP_001261516.1  uncharacterized protein Dmel_CG8560, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261516.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q961J8, Q9VS68
      Conserved Domains (2) summary
      cd03860
      Location:123 → 414
      M14_CP_A-B_like; Peptidase M14 carboxypeptidase subfamily A/B-like
      pfam02244
      Location:29 → 98
      Propep_M14; Carboxypeptidase activation peptide
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q961J8 Q961J8

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