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    Spred Sprouty-related protein with EVH-1 domain [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36643, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Spredprovided by FlyBase
    Official Full Name
    Sprouty-related protein with EVH-1 domainprovided by FlyBase
    Primary source
    FLYBASE:FBgn0020767
    Locus tag
    Dmel_CG10155
    See related
    AllianceGenome:FB:FBgn0020767
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AE33; CG10155; Dm AE33; Dmel\CG10155; dSPRED; spred
    Summary
    Predicted to enable protein kinase binding activity. Involved in negative regulation of ERK1 and ERK2 cascade. Located in cytosol. Is expressed in several structures, including adult brain cell body rind; adult head; embryonic dorsal epidermis; eye photoreceptor cell; and ganglia. Human ortholog(s) of this gene implicated in Legius syndrome and Noonan syndrome. Orthologous to several human genes including SPRED2 (sprouty related EVH1 domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Spred in Genome Data Viewer
    Location:
    51C2-51C2; 2-72 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14759646..14769423, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10647151..10656928, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase (ubiquinone) B15 subunit Neighboring gene uncharacterized protein Neighboring gene TRAPP subunit 31 Neighboring gene antisense RNA:CR42254 Neighboring gene Boundary element-associated factor of 32kD Neighboring gene knot

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identifying targets of the rough homeobox gene of Drosophila: evidence that rhomboid functions in eye development. Freeman M, et al. Development, 1992 Oct. PMID 1363086
    2. Identification of a dominant negative mutant of Sprouty that potentiates fibroblast growth factor- but not epidermal growth factor-induced ERK activation. Sasaki A, et al. J Biol Chem, 2001 Sep 28. PMID 11495895
    3. EVH1/WH1 domains of VASP and WASP proteins belong to a large family including Ran-binding domains of the RanBP1 family. Callebaut I, et al. FEBS Lett, 1998 Dec 18. PMID 9883880
    4. A Drosophila gene regulated by rough and glass shows similarity to ena and VASP. DeMille MM, et al. Gene, 1996 Dec 12. PMID 8996093
    5. Spred is a Sprouty-related suppressor of Ras signalling. Wakioka T, et al. Nature, 2001 Aug 9. PMID 11493923

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Sprouty-related protein with EVH-1 domain
    Names
    CG10155-PA
    CG10155-PB
    CG10155-PC
    Spred-PA
    Spred-PB
    Spred-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      14759646..14769423 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274050.2 → NP_001260979.1  Sprouty-related protein with EVH-1 domain, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260979.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KG11
      Conserved Domains (2) summary
      cd10574
      Location:9 → 122
      EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
      pfam05210
      Location:315 → 413
      Sprouty; Sprouty protein (Spry)

    2. NM_001274049.2 → NP_001260978.1  Sprouty-related protein with EVH-1 domain, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260978.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F0JAK5
      Conserved Domains (2) summary
      cd10574
      Location:9 → 122
      EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
      pfam05210
      Location:291 → 397
      Sprouty; Sprouty protein (Spry)

    3. NM_137144.4 → NP_610988.1  Sprouty-related protein with EVH-1 domain, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610988.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K0G4
      Related
      FBpp0086597
      Conserved Domains (2) summary
      cd10574
      Location:9 → 122
      EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
      pfam05210
      Location:313 → 419
      Sprouty; Sprouty protein (Spry)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KG11 A0A0B4KG11
    F0JAK5 F0JAK5
    Q7K0G4 Q7K0G4
    Q95TD3 Q95TD3

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