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    slam slow as molasses [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33890, updated on 9-Dec-2024

    Summary

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    Official Symbol
    slamprovided by FlyBase
    Official Full Name
    slow as molassesprovided by FlyBase
    Primary source
    FLYBASE:FBgn0043854
    Locus tag
    Dmel_CG9506
    See related
    AllianceGenome:FB:FBgn0043854
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9506; Dmel\CG9506; Slam; wdo
    Summary
    Involved in germ cell migration; plasma membrane invagination; and syncytial embryo cellularization. Located in cellularization cleavage furrow invagination front and cleavage furrow. Is expressed in furrow canal; organism; and spermatozoon. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See slam in Genome Data Viewer
    Location:
    26C4-26C4; 2-19 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6372388..6377284)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6372388..6377284)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44778 Neighboring gene Neprilysin-like 4 Neighboring gene Dpr-interacting protein epsilon Neighboring gene Neprilysin-like 5 Neighboring gene Neprilysin-like 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The plasma membrane flattens out to fuel cell-surface growth during Drosophila cellularization. Figard L, et al. Dev Cell, 2013 Dec 23. PMID 24316147, Free PMC Article
    2. Membrane Supply and Demand Regulates F-Actin in a Cell Surface Reservoir. Figard L, et al. Dev Cell, 2016 May 9. PMID 27165556, Free PMC Article
    3. Localization and translation control of slam in Drosophila cellularization. Yan S, et al. Fly (Austin), 2018. PMID 30211628, Free PMC Article
    4. In Vivo Force Application Reveals a Fast Tissue Softening and External Friction Increase during Early Embryogenesis. D'Angelo A, et al. Curr Biol, 2019 May 6. PMID 31031116, Free PMC Article
    5. Flow-dependent myosin recruitment during Drosophila cellularization requires zygotic dunk activity. He B, et al. Development, 2016 Jul 1. PMID 27226317, Free PMC Article

    See all (90) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Biochemical interaction of slam mRNA and protein as demonstrated by specific co-immunoprecipitation from embryonic lysate. The intimate relationship of slam mRNA and protein may constitute a positive feedback loop that facilitates and controls timely and rapid accumulation of Slam protein at the prospective basal region.
      Title: Slam protein dictates subcellular localization and translation of its own mRNA.
    2. Following the onset of zygotic gene expression, Slam and Nullo together stabilise the retracting metaphase furrow and Slam triggers invagination of the cleavage furrow.
      Title: Function and dynamics of slam in furrow formation in early Drosophila embryo.
    3. Accumulation of slam mRNA and protein at the presumptive invagination site provides a spatial and temporal trigger for RhoGEF2-Rho1 signalling.
      Title: Localization of RhoGEF2 during Drosophila cellularization is developmentally controlled by Slam.
    4. Slam is required for the localization of a signal to the basal side of blastoderm cells that is needed later in the posterior midgut to guide germ cells.
      Title: Slow as molasses is required for polarized membrane growth and germ cell migration in Drosophila.
    5. analysis of the slow as molasses (slam) gene provides a potential link between somatic cell formation and germ cell migration
      Title: Germ cell migration: as slow as molasses.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in cellularization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellularization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cleavage furrow formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cleavage furrow ingression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ cell migration TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in membrane organization NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in protein localization NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in syncytial embryo cellularization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cellularization cleavage furrow invagination front IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cleavage furrow IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    slow as molasses
    Names
    CG9506-PB
    CG9506-PC
    slam-PB
    slam-PC
    waldo

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6372388..6377284
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135176.3 → NP_609020.3  slow as molasses, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609020.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8WHJ2, Q9VME5

    2. NM_001298739.1 → NP_001285668.1  slow as molasses, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285668.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8WHJ2, Q9VME5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VME5 Q9VME5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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