U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Hsp67Ba Heat shock gene 67Ba [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39076, updated on 17-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Hsp67Baprovided by FlyBase
    Official Full Name
    Heat shock gene 67Baprovided by FlyBase
    Primary source
    FLYBASE:FBgn0001227
    Locus tag
    Dmel_CG4167
    See related
    AllianceGenome:FB:FBgn0001227
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4167; Dmel22.2; Dmel\CG4167; DmHsp67; DROHSP; DROHSP1; gene 1; gene1; Hsp-G1; hsp67Ba; HSP67BA; small hsp locus 67B
    Summary
    Predicted to enable unfolded protein binding activity. Involved in response to heat. Predicted to be active in cytoplasm and nucleus. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in cataract 9 multiple types. Orthologous to human CRYAA (crystallin alpha A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Hsp67Ba in Genome Data Viewer
    Location:
    67B2-67B2; 3-29 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9377802..9379534, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9370902..9372634, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Heat shock protein 26 Neighboring gene antisense RNA:CR43481 Neighboring gene Heat shock protein 23 Neighboring gene Heat shock protein 27 Neighboring gene pseudo

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Multiple interacting elements delineate an ecdysone-dependent regulatory region with secondary responsive character. Rogulski KR, et al. J Mol Biol, 1995 Jun 2. PMID 7783195
    2. Characterization of the shsp genes in Drosophila buzzatii and association between the frequency of Valine mutations in hsp23 and climatic variables along a longitudinal gradient in Australia. Frydenberg J, et al. Cell Stress Chaperones, 2010 May. PMID 19806471, Free PMC Article
    3. Locus 67B of Drosophila melanogaster contains seven, not four, closely related heat shock genes. Ayme A, et al. EMBO J, 1985 Nov. PMID 3933974, Free PMC Article
    4. A Drosophila heat shock gene from locus 67B is expressed during embryogenesis and pupation. Pauli D, et al. J Mol Biol, 1987 Nov 20. PMID 3123699
    5. Response to heat shock of gene 1, a Drosophila melanogaster small heat shock gene, is developmentally regulated. Vazquez J. Mol Gen Genet, 1991 May. PMID 1903835

    See all (81) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chaperone-mediated protein folding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to heat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to heat IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    heat shock gene 67Ba
    Names
    CG4167-PA
    Hsp67Ba-PA
    gene 1
    heat shock protein family B (small) member 1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      9377802..9379534 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079274.3 → NP_523998.1  heat shock gene 67Ba [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523998.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P05812, Q5U130, Q9VSX4
      Related
      FBpp0076223
      Conserved Domains (2) summary
      cd06526
      Location:124 → 200
      metazoan_ACD; Alpha-crystallin domain (ACD) of metazoan alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are ...
      cl26247
      Location:218 → 381
      DNA_pol3_delta2; DNA polymerase III, delta subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P05812.2 P05812

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous