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    ppk8 pickpocket 8 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 318213, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ppk8provided by FlyBase
    Official Full Name
    pickpocket 8provided by FlyBase
    Primary source
    FLYBASE:FBgn0052792
    Locus tag
    Dmel_CG32792
    See related
    AllianceGenome:FB:FBgn0052792
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG32792; Dmel\CG32792; ppk29; Ppk8
    Summary
    Predicted to enable ligand-gated sodium channel activity. Predicted to be involved in sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult fat body. Orthologous to several human genes including ASIC1 (acid sensing ion channel subunit 1); ASIC2 (acid sensing ion channel subunit 2); and ASIC3 (acid sensing ion channel subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ppk8 in Genome Data Viewer
    Location:
    3D6-3D6; 1-3 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (3557812..3572000)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (3451845..3466033)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44999 Neighboring gene Dpr-interacting protein alpha Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR34335 Neighboring gene Allatostatin A receptor 1 Neighboring gene uncharacterized protein Neighboring gene Insulin-like peptide 7 Neighboring gene Poly(ADP-ribose) glycohydrolase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The amiloride-sensitive epithelial Na+ channel PPK28 is essential for drosophila gustatory water reception. Chen Z, et al. J Neurosci, 2010 May 5. PMID 20445050, Free PMC Article
    2. ppk23-Dependent chemosensory functions contribute to courtship behavior in Drosophila melanogaster. Lu B, et al. PLoS Genet, 2012. PMID 22438833, Free PMC Article
    3. A presynaptic ENaC channel drives homeostatic plasticity. Younger MA, et al. Neuron, 2013 Sep 18. PMID 23973209, Free PMC Article
    4. Sensory functions for degenerin/epithelial sodium channels (DEG/ENaC). Ben-Shahar Y. Adv Genet, 2011. PMID 22099690, Free PMC Article
    5. Evolution of the Insect PPK Gene Family. Latorre-Estivalis JM, et al. Genome Biol Evol, 2021 Sep 1. PMID 34390578, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ligand-gated sodium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sodium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pickpocket 8
    Names
    CG32792-PG
    CG32792-PH
    ppk8-PG
    ppk8-PH

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      3557812..3572000
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144679.2 → NP_001138151.2  pickpocket 8, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138151.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z123, C3KKB3
      Conserved Domains (1) summary
      pfam00858
      Location:52 → 371
      ASC; Amiloride-sensitive sodium channel

    2. NM_001042795.3 → NP_001036260.3  pickpocket 8, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036260.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KHW3
      Conserved Domains (1) summary
      pfam00858
      Location:42 → 508
      ASC; Amiloride-sensitive sodium channel
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7Z123 B7Z123
    Q0KHW3 Q0KHW3

    Gene LinkOut

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