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    Cchl Cytochrome c heme lyase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42590, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cchlprovided by FlyBase
    Official Full Name
    Cytochrome c heme lyaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038925
    Locus tag
    Dmel_CG6022
    See related
    AllianceGenome:FB:FBgn0038925
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cchl; cchL; CG6022; Dmel\CG6022
    Summary
    Predicted to enable holocytochrome-c synthase activity. Predicted to be located in mitochondrial intermembrane space. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; gut section; larval muscle cell; and larval muscle system. Human ortholog(s) of this gene implicated in linear skin defects with multiple congenital anomalies 1 and microphthalmia. Orthologous to human HCCS (holocytochrome c synthase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cchl in Genome Data Viewer
    Location:
    94A1-94A1; 3-74 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22025975..22027480, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (17851697..17853202, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene mitofilin Neighboring gene mitochondrial ribosomal protein L35 Neighboring gene uncharacterized protein Neighboring gene NADH dehydrogenase (ubiquinone) 42 kDa subunit Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An efficient genetic screen in Drosophila to identify nuclear-encoded genes with mitochondrial function. Liao TS, et al. Genetics, 2006 Sep. PMID 16849596, Free PMC Article
    2. A Common Suite of Coagulation Proteins Function in Drosophila Muscle Attachment. Green N, et al. Genetics, 2016 Nov. PMID 27585844, Free PMC Article
    3. Introgression in the Drosophila subobscura--D. Madeirensis sister species: evidence of gene flow in nuclear genes despite mitochondrial differentiation. Herrig DK, et al. Evolution, 2014 Mar. PMID 24152112, Free PMC Article
    4. A genome-wide RNAi screen draws a genetic framework for transposon control and primary piRNA biogenesis in Drosophila. Muerdter F, et al. Mol Cell, 2013 Jun 6. PMID 23665228, Free PMC Article
    5. Maintenance of mitochondrial integrity in midbrain dopaminergic neurons governed by a conserved developmental transcription factor. Miozzo F, et al. Nat Commun, 2022 Mar 17. PMID 35301315, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables holocytochrome-c synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables holocytochrome-c synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables holocytochrome-c synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial intermembrane space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome c heme lyase
    Names
    CG6022-PA
    CG6022-PB
    Cchl-PA
    Cchl-PB
    cytochrome c haem lyase
    NP_001262820.1
    NP_651003.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      22025975..22027480 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142746.3 → NP_651003.1  cytochrome c heme lyase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651003.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VD55
      Related
      FBpp0083583
      Conserved Domains (1) summary
      pfam01265
      Location:13 → 260
      Cyto_heme_lyase; Cytochrome c/c1 heme lyase

    2. NM_001275891.1 → NP_001262820.1  cytochrome c heme lyase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262820.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VD55
      Conserved Domains (1) summary
      pfam01265
      Location:13 → 260
      Cyto_heme_lyase; Cytochrome c/c1 heme lyase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VD55 Q9VD55

    Gene LinkOut

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