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    tank tank [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33684, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tankprovided by FlyBase
    Official Full Name
    tankprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031635
    Locus tag
    Dmel_CG15626
    See related
    AllianceGenome:FB:FBgn0031635
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15626; Dmel\CG15626
    Summary
    Involved in positive regulation of response to ethanol. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including adult head; adult insulin secreting cell of pars intercerebralis; adult mushroom body; cuboidal/columnar epithelium; and ganglia. Orthologous to human EI24 (EI24 autophagy associated transmembrane protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See tank in Genome Data Viewer
    Location:
    25A8-25A8; 2-13 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (4835335..4837999, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (4835335..4837999, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene mir-4912 stem loop Neighboring gene Farnesyl transferase alpha subunit Neighboring gene Ionotropic receptor 25a Neighboring gene uncharacterized protein Neighboring gene mextli

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The novel gene tank, a tumor suppressor homolog, regulates ethanol sensitivity in Drosophila. Devineni AV, et al. J Neurosci, 2013 May 8. PMID 23658154, Free PMC Article
    2. Drosophila and Caenorhabditis elegans as Discovery Platforms for Genes Involved in Human Alcohol Use Disorder. Grotewiel M, et al. Alcohol Clin Exp Res, 2015 Aug. PMID 26173477, Free PMC Article
    3. Molecular definitions of autophagy and related processes. Galluzzi L, et al. EMBO J, 2017 Jul 3. PMID 28596378, Free PMC Article
    4. Genetic annotation of gain-of-function screens using RNA interference and in situ hybridization of candidate genes in the Drosophila wing. Molnar C, et al. Genetics, 2012 Oct. PMID 22798488, Free PMC Article
    5. Identification of novel Drosophila neural precursor genes using a differential embryonic head cDNA screen. Brody T, et al. Mech Dev, 2002 Apr. PMID 11900973

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in macroautophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of response to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tank
    Names
    CG15626-PA
    CG15626-PB
    tank-PA
    tank-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      4835335..4837999 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164597.2 → NP_723014.1  tank, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723014.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VR33
      Related
      FBpp0077104
      Conserved Domains (1) summary
      pfam07264
      Location:164 → 296
      EI24; Etoposide-induced protein 2.4 (EI24)

    2. NM_135020.3 → NP_608864.1  tank, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608864.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VR33
      Related
      FBpp0077103
      Conserved Domains (1) summary
      pfam07264
      Location:164 → 296
      EI24; Etoposide-induced protein 2.4 (EI24)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VR33 Q9VR33

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