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    Hs6st Heparan sulfate 6-O-sulfotransferase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42380, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Hs6stprovided by FlyBase
    Official Full Name
    Heparan sulfate 6-O-sulfotransferaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038755
    Locus tag
    Dmel_CG4451
    See related
    AllianceGenome:FB:FBgn0038755
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11683; CG17188; CG18533; CG4451; dHS6ST; Dmel\CG4451; DmHs6st; hs6st; HS6ST
    Summary
    Enables heparan sulfate 6-O-sulfotransferase activity. Involved in several processes, including heparan sulfate proteoglycan biosynthetic process, enzymatic modification; imaginal disc-derived wing margin morphogenesis; and regulation of imaginal disc growth. Predicted to be located in membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including dorsal ectoderm; dorsal epidermis primordium; dorsal pharyngeal muscle cell; embryonic/larval dorsal vessel; and tracheal primordium. Human ortholog(s) of this gene implicated in Paganini-Miozzo syndrome and hypogonadotropic hypogonadism 15 with or without anosmia. Orthologous to several human genes including HS6ST1 (heparan sulfate 6-O-sulfotransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Hs6st in Genome Data Viewer
    Location:
    92B8-92C1; 3-67 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19929277..20008512, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (15754999..15834234, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene miranda Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Mediator complex subunit 25 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss of heparan sulfate in the niche leads to tumor-like germ cell growth in the Drosophila testis. Levings DC, et al. Glycobiology, 2018 Dec 1. PMID 29069438, Free PMC Article
    2. Dynamic Interactions Between the Genome and an Endogenous Retrovirus: Tirant in Drosophila simulans Wild-Type Strains. Fablet M, et al. G3 (Bethesda), 2019 Mar 7. PMID 30658967, Free PMC Article
    3. The role of Drosophila heparan sulfate 6-O-endosulfatase in sulfation compensation. Dejima K, et al. J Biol Chem, 2013 Mar 1. PMID 23339195, Free PMC Article
    4. Heparan sulfate regulates the number and centrosome positioning of Drosophila male germline stem cells. Levings DC, et al. Mol Biol Cell, 2016 Mar 15. PMID 26792837, Free PMC Article
    5. In vivo manipulation of heparan sulfate structure and its effect on Drosophila development. Kamimura K, et al. Glycobiology, 2011 May. PMID 21147759, Free PMC Article

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    mobile_element

    • Loc: c20001838-20001699 mobile_element_type = transposon:FB{}4816

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heparan sulfate 6-O-sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heparan sulfate 6-O-sulfotransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chaeta development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heparan sulfate proteoglycan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heparan sulfate proteoglycan biosynthetic process, enzymatic modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heparan sulfate proteoglycan biosynthetic process, enzymatic modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing margin morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in open tracheal system development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in open tracheal system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of imaginal disc growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    heparan sulfate 6-O-sulfotransferase
    Names
    6-O sulfotransferase
    6-O-sulfotransferase
    CG4451-PA
    CG4451-PB
    HS 6-O-sulfotransferase
    Hs6st-PA
    Hs6st-PB
    NP_001262750.1
    NP_524409.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      19929277..20008512 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275821.1 → NP_001262750.1  heparan sulfate 6-O-sulfotransferase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262750.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960R4, Q968Z7, Q9VDR6
      Conserved Domains (1) summary
      pfam03567
      Location:144 → 410
      Sulfotransfer_2; Sulfotransferase family

    2. NM_079685.3 → NP_524409.2  heparan sulfate 6-O-sulfotransferase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524409.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960R4, Q968Z7, Q9VDR6
      Related
      FBpp0083255
      Conserved Domains (1) summary
      pfam03567
      Location:144 → 410
      Sulfotransfer_2; Sulfotransferase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q968Z7 Q968Z7
    Q9VDR6 Q9VDR6

    Gene LinkOut

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