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    Ank Ankyrin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43770, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Ankprovided by FlyBase
    Official Full Name
    Ankyrinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0011747
    Locus tag
    Dmel_CG1651
    See related
    AllianceGenome:FB:FBgn0011747
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ank; ANK; CG1651; CG32008; dank1; Dank1; DAnk1; Dmel\CG1651
    Summary
    Predicted to enable cytoskeletal anchor activity; spectrin binding activity; and transmembrane transporter binding activity. Predicted to be involved in protein localization to plasma membrane. Located in plasma membrane and spectrosome. Is expressed in several structures, including adult head; adult heart; germline stem cell; ovary; and salivary gland body primordium. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); ankyrin-B-related cardiac arrhythmia; autosomal recessive intellectual developmental disorder 37; bipolar disorder; and heart conduction disease (multiple). Orthologous to several human genes including ANK1 (ankyrin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ank in Genome Data Viewer
    Location:
    102A3-102A3; 4-0 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (115074..129849, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (135700..150475, complement)

    Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Ribosomal protein S3A Neighboring gene pangolin Neighboring gene long non-coding RNA:CR43956 Neighboring gene anne boleyn Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ankyrin and beta-spectrin accumulate independently of alpha-spectrin in Drosophila. Dubreuil RR, et al. Proc Natl Acad Sci U S A, 1994 Oct 25. PMID 7937942, Free PMC Article
    2. Patterns of genetic variation at a chromosome 4 locus of Drosophila melanogaster and D. simulans. Jensen MA, et al. Genetics, 2002 Feb. PMID 11861556, Free PMC Article
    3. Sodium channel beta subunits mediate homophilic cell adhesion and recruit ankyrin to points of cell-cell contact. Malhotra JD, et al. J Biol Chem, 2000 Apr 14. PMID 10753953
    4. Neuroglian-mediated cell adhesion induces assembly of the membrane skeleton at cell contact sites. Dubreuil RR, et al. J Cell Biol, 1996 May. PMID 8636238, Free PMC Article
    5. Hydrogen bonding progressively strengthens upon transfer of the protein urea-denatured state to water and protecting osmolytes. Holthauzen LM, et al. Biochemistry, 2010 Feb 16. PMID 20073511, Free PMC Article

    See all (109) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In this study, use of osmolyte cosolvents demonstrates that hydrogen-bonding contributions can be separated from hydrophobic interactions in the denatured state of a truncated notch ankyrin protein domain.
      Title: Hydrogen bonding progressively strengthens upon transfer of the protein urea-denatured state to water and protecting osmolytes.
    2. Molecular mechanisms that enhance synapse stability despite persistent disruption of the spectrin/Ank/microtubule cytoskeleton are reported.
      Title: Molecular mechanisms that enhance synapse stability despite persistent disruption of the spectrin/ankyrin/microtubule cytoskeleton.
    3. the Spectrin network is playing a role independently of Ankyrin in the establishment and/or maintenance of specialized membrane domains containing guidance molecules that ensure the fidelity of axon repulsion at the midline
      Title: beta-Spectrin functions independently of Ankyrin to regulate the establishment and maintenance of axon connections in the Drosophila embryonic CNS.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c119039-118965 mobile_element_type = transposon:INE-1{}4171
    • Loc: c126666-125492 mobile_element_type = transposon:Tc1{}1485
    • Loc: c128439-128086 mobile_element_type = transposon:S2{}1486
    • Loc: c128824-127987 mobile_element_type = transposon:INE-1{}4640
    • Loc: c129057-128965 mobile_element_type = transposon:INE-1{}4643

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cytoskeletal anchor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables spectrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spectrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ankyrin
    Names
    Ank-PB
    Ank-PC
    Ank-PD
    Ank-PE
    Ank1
    CG1651-PB
    CG1651-PC
    CG1651-PD
    CG1651-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004353.4 Reference assembly

      Range
      115074..129849 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001169348.2 → NP_001162819.1  ankyrin, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162819.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KIE7, Q24241
      Conserved Domains (7) summary
      smart00218
      Location:930 → 1034
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:491 → 616
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08317
      Location:1439 → 1521
      Death_ank; Death domain associated with Ankyrins
      pfam12796
      Location:633 → 723
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:300 → 353
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:582 → 636
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:496 → 527
      ANK; ANK repeat [structural motif]

    2. NM_175927.3 → NP_787123.1  ankyrin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_787123.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KIE7, Q24241
      Related
      FBpp0088238
      Conserved Domains (7) summary
      smart00218
      Location:930 → 1034
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:491 → 616
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08317
      Location:1439 → 1521
      Death_ank; Death domain associated with Ankyrins
      pfam12796
      Location:633 → 723
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:300 → 353
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:582 → 636
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:496 → 527
      ANK; ANK repeat [structural motif]

    3. NM_175928.3 → NP_787124.1  ankyrin, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_787124.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KIE7, Q24241
      Related
      FBpp0088239
      Conserved Domains (7) summary
      smart00218
      Location:930 → 1034
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:491 → 616
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08317
      Location:1439 → 1521
      Death_ank; Death domain associated with Ankyrins
      pfam12796
      Location:633 → 723
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:300 → 353
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:582 → 636
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:496 → 527
      ANK; ANK repeat [structural motif]

    4. NM_175926.3 → NP_787122.1  ankyrin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_787122.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KIE7, Q24241
      Related
      FBpp0088240
      Conserved Domains (7) summary
      smart00218
      Location:930 → 1034
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:491 → 616
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08317
      Location:1439 → 1521
      Death_ank; Death domain associated with Ankyrins
      pfam12796
      Location:633 → 723
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:300 → 353
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:582 → 636
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:496 → 527
      ANK; ANK repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0KIE7 Q0KIE7
    Q24241 Q24241
    Q95TU4 Q95TU4
    Q95UF0 Q95UF0

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