Hsp26 Heat shock protein 26 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Hsp26provided by FlyBase
Official Full Name: Heat shock protein 26provided by FlyBase
Primary source: FLYBASE:FBgn0001225
Locus tag: Dmel_CG4183
See related: AllianceGenome:FB:FBgn0001225
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 26; 26K; CG4183; Dmel23.0; Dmel\CG4183; DmHsp26; hsp 26; Hsp 26; hsp26; HSP26; small hsp locus 67B
Summary: Enables myosin binding activity and unfolded protein binding activity. Involved in several processes, including cold acclimation; determination of adult lifespan; and protein folding. Located in cytosol. Is expressed in several structures, including Malpighian tubule primordium; embryonic/larval midgut primordium; ganglia; germline cell; and gut section. Human ortholog(s) of this gene implicated in cataract 9 multiple types. Orthologous to human CRYAA (crystallin alpha A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 67B2-67B2; 3-29 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (9376418..9377427, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (9369518..9370527, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Small heat shock proteins determine synapse number and neuronal activity during development.
Title: Small heat shock proteins determine synapse number and neuronal activity during development.
The study provides evidence for the attenuation of cellular and functional decline in aged Drosophila after prolonged DCA exposure and the effect of hsp27 modulation which further incites studies towards the therapeutic application of DCA.
Title: Long-term dietary exposure to low concentration of dichloroacetic acid promoted longevity and attenuated cellular and functional declines in aged Drosophila melanogaster.
Hsp26 overexpression in larva had only a small thermoprotective effect on locomotion and no effect on neural function.
Title: Tissue-specific targeting of Hsp26 has no effect on heat resistance of neural function in larval Drosophila.
The functional similarities and differences of neuronal expression of hsp26 and hsp27 in adult Drosophila were demonstrated.
Title: The effect of neuronal expression of heat shock proteins 26 and 27 on lifespan, neurodegeneration, and apoptosis in Drosophila.
Data show that overexpression of either heat-shock proteins 26 or 27 extended the mean lifespan by 30%, and the flies also displayed increased stress resistance.
Title: Multiple-stress analysis for isolation of Drosophila longevity genes.
GAGA factor and the TFIID complex collaborate in generating an open chromatin structure at the Drosophila melanogaster hsp26 promoter.
Title: GAGA factor and the TFIID complex collaborate in generating an open chromatin structure at the Drosophila melanogaster hsp26 promoter.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables myosin binding	IPI Inferred from Physical Interaction more info	PubMed
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables unfolded protein binding	IDA Inferred from Direct Assay more info	PubMed
enables unfolded protein binding	ISM Inferred from Sequence Model more info	PubMed

Process	Evidence Code	Pubs
involved_in chaperone-mediated protein folding	IDA Inferred from Direct Assay more info	PubMed
involved_in chaperone-mediated protein folding	ISM Inferred from Sequence Model more info	PubMed
involved_in cold acclimation	IEP Inferred from Expression Pattern more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein refolding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein refolding	IDA Inferred from Direct Assay more info	PubMed
involved_in response to heat	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to heat	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: heat shock protein 26

Names: CG4183-PA; CG4183-PB; Hsp 26; Hsp26-PA; Hsp26-PB; heat shock protein hsp26; hsp26; protein 26

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

9376418..9377427 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001300071.1 → NP_001287000.1 heat shock protein 26, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287000.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P02517, Q9VSX3

UniProtKB/TrEMBL

X2JGG6

Conserved Domains (2) summary

cd06526
Location:85 → 163

metazoan_ACD; Alpha-crystallin domain (ACD) of metazoan alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are ...

COG0071
Location:87 → 179

IbpA; Molecular chaperone IbpA, HSP20 family [Posttranslational modification, protein turnover, chaperones]
NM_079273.3 → NP_523997.1 heat shock protein 26, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523997.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P02517, Q9VSX3

UniProtKB/TrEMBL

X2JGG6

Related

FBpp0076224

Conserved Domains (2) summary

cd06526
Location:85 → 163

metazoan_ACD; Alpha-crystallin domain (ACD) of metazoan alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are ...

COG0071
Location:87 → 179

IbpA; Molecular chaperone IbpA, HSP20 family [Posttranslational modification, protein turnover, chaperones]