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    Uck Uridine-cytidine kinase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42894, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Uckprovided by FlyBase
    Official Full Name
    Uridine-cytidine kinaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263398
    Locus tag
    Dmel_CG6364
    See related
    AllianceGenome:FB:FBgn0263398
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6364; CR42873; Dmel\CG6364; Uck2
    Old locus tag
    Dmel_CR42873
    Summary
    Predicted to enable cytidine kinase activity and uridine kinase activity. Predicted to be active in cytoplasm. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; gland; gut section; and salivary gland body primordium. Orthologous to several human genes including UCK1 (uridine-cytidine kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Uck in Genome Data Viewer
    Location:
    95F10-95F10; 3-84 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24290172..24293371)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20115894..20119093)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45662 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene crumbs Neighboring gene Nuclear polyadenosine RNA-binding 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ehrlichia chaffeensis replication sites in adult Drosophila melanogaster. Drolia R, et al. Int J Med Microbiol, 2013 Jan. PMID 23306065, Free PMC Article
    2. Severe Fertility Effects of sheepish Sperm Caused by Failure To Enter Female Sperm Storage Organs in Drosophila melanogaster. Tomaru M, et al. G3 (Bethesda), 2018 Jan 4. PMID 29158336, Free PMC Article
    3. Transcripts immunoprecipitated with Sxl protein in primordial germ cells of Drosophila embryos. Ota R, et al. Dev Growth Differ, 2017 Dec. PMID 29124738
    4. Identification of critical host mitochondrion-associated genes during Ehrlichia chaffeensis infections. Von Ohlen T, et al. Infect Immun, 2012 Oct. PMID 22851751, Free PMC Article
    5. Ribbon regulates morphogenesis of the Drosophila embryonic salivary gland through transcriptional activation and repression. Loganathan R, et al. Dev Biol, 2016 Jan 1. PMID 26477561, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytidine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables uridine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Uridine-cytidine kinase
    Names
    CG6364-PA
    CG6364-PB
    CG6364-PC
    CG6364-PD
    CG6364-PE
    Uck-PA
    Uck-PB
    Uck-PC
    Uck-PD
    Uck-PE
    NP_001138105.1
    NP_001247281.1
    NP_001247282.1
    NP_001247283.1
    NP_651241.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24290172..24293371
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001260352.2 → NP_001247281.1  Uridine-cytidine kinase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247281.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H1UUH6, Q9VC99
      UniProtKB/TrEMBL
      Q8MRJ1
      Conserved Domains (1) summary
      cd02023
      Location:29 → 236
      UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

    2. NM_001144633.3 → NP_001138105.1  Uridine-cytidine kinase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138105.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0P8, Q8MRJ1
      Conserved Domains (1) summary
      cd02023
      Location:29 → 235
      UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

    3. NM_001260353.2 → NP_001247282.1  Uridine-cytidine kinase, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247282.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H1UUH6, Q9VC99
      UniProtKB/TrEMBL
      Q8MRJ1
      Conserved Domains (1) summary
      cd02023
      Location:29 → 236
      UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

    4. NM_001260354.2 → NP_001247283.1  Uridine-cytidine kinase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247283.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H1UUH6, Q9VC99
      UniProtKB/TrEMBL
      Q8MRJ1
      Conserved Domains (1) summary
      cd02023
      Location:29 → 236
      UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

    5. NM_142984.2 → NP_651241.1  Uridine-cytidine kinase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651241.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H1UUH6, Q9VC99
      UniProtKB/TrEMBL
      Q8MRJ1
      Related
      FBpp0083986
      Conserved Domains (1) summary
      cd02023
      Location:29 → 236
      UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7Z0P8 B7Z0P8
    Q8MRJ1 Q8MRJ1
    Q9VC99.1 Q9VC99

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