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    Prim1 DNA primase subunit 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38942, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Prim1provided by FlyBase
    Official Full Name
    DNA primase subunit 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0011762
    Locus tag
    Dmel_CG7108
    See related
    AllianceGenome:FB:FBgn0011762
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0140519.257; CG7108; Dmel\CG7108; Dmpol alpha; DNA polalpha; dnapol alpha 50; DNApol-alpha; DNApol-alpha50; DNApolalpha; DNApolalpha-50; DNApolalpha50; Dpri50; Pol; pol alpha; Pol-alpha50; POLA; polalpha; Polalpha; Polalpha 50kDa; Polalpha 50KDa; polalpha50; Polalpha50; PRI1
    Summary
    Enables DNA primase activity. Involved in DNA replication, synthesis of primer. Part of alpha DNA polymerase:primase complex. Orthologous to human PRIM1 (DNA primase subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Prim1 in Genome Data Viewer
    Location:
    66C7-66C8; 3-24 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8340314..8344404)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8333414..8337504)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Cuticular protein 66Cb Neighboring gene Peroxin 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene GTPase activating protein and centrosome-associated

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The 50-kDa primase subunit of Drosophila melanogaster DNA polymerase alpha. Molecular characterization of the gene and functional analysis of the overexpressed protein. Bakkenist CJ, et al. J Biol Chem, 1994 Oct 28. PMID 7929411
    2. A high molecular weight DNA polymerase from Drosophila melanogaster embryos. Purification, structure, and partial characterization. Banks GR, et al. J Biol Chem, 1979 Oct 10. PMID 114515
    3. The Drosophila melanogaster UMP-CMP kinase cDNA encodes an N-terminal mitochondrial import signal. Curbo S, et al. Biochem Biophys Res Commun, 2003 Nov 14. PMID 14592433
    4. Recollections of a DNA enzymologist. Lehman IR. Protein Sci, 1998 Apr. PMID 9568914, Free PMC Article
    5. Kinetics of deoxyribonucleotide insertion and extension at abasic template lesions in different sequence contexts using HIV-1 reverse transcriptase. Cai H, et al. J Biol Chem, 1993 Nov 5. PMID 7693691

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA primase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA primase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA primase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication, synthesis of primer IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication, synthesis of primer IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA replication, synthesis of primer IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA-templated DNA replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of alpha DNA polymerase:primase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of alpha DNA polymerase:primase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA primase subunit 1
    Names
    CG7108-PA
    DNA polymerase 50K
    DNA polymerase alpha
    DNA polymerase alpha 46,000 gamma subunit
    DNA polymerase alpha 50 kda primase subunit
    DNA polymerase alpha 50,000 gamma subunit
    DNA polymerase alpha 50kD
    DNA polymerase alpha 50kD subunit
    DNA-polymerase alpha
    Prim1-PA
    p50 subunit of DNA polymerase alpha
    NP_523972.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      8340314..8344404
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079248.4 → NP_523972.2  DNA primase subunit 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523972.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24317, Q9VSI0
      Related
      FBpp0076330
      Conserved Domains (1) summary
      cd04860
      Location:41 → 372
      AE_Prim_S; AE_Prim_S: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. Primases are DNA-dependent RNA polymerases which synthesis the short RNA primers required for DNA replication. In addition to its ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24317.2 Q24317

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