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    Dyrk3 Dual-specificity tyrosine phosphorylation-regulated kinase 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3885567, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dyrk3provided by FlyBase
    Official Full Name
    Dual-specificity tyrosine phosphorylation-regulated kinase 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0027101
    Locus tag
    Dmel_CG40478
    See related
    AllianceGenome:FB:FBgn0027101
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE60792; CG40478; DDYRK3; Dm3; DmDyrk3; Dmel\CG40478; DYRK3; FBtr0100406
    Summary
    Predicted to enable protein serine/threonine kinase activity and protein serine/threonine/tyrosine kinase activity. Predicted to be active in cytoplasm; cytoskeleton; and nucleus. Is expressed in eye disc morphogenetic furrow; organism; and third segment of antenna. Orthologous to human DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2) and DYRK3 (dual specificity tyrosine phosphorylation regulated kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dyrk3 in Genome Data Viewer
    Location:
    102F8-102F8; 4-0 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (1225089..1230713, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (1228815..1234439, complement)

    Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Phosphatidylinositol 5-phosphate 4-kinase Neighboring gene mitf Neighboring gene Calcium-dependent secretion activator

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. dDYRK2: a novel dual-specificity tyrosine-phosphorylation-regulated kinase in Drosophila. Lochhead PA, et al. Biochem J, 2003 Sep 1. PMID 12786602, Free PMC Article
    2. Calcium influx: beyond 'current' biology. Robinson LC, et al. Curr Biol, 2006 Jul 25. PMID 16860734
    3. Characterization of a domain that transiently converts class 2 DYRKs into intramolecular tyrosine kinases. Kinstrie R, et al. Sci Signal, 2010 Mar 2. PMID 20197545
    4. Drosophila Dyrk2 plays a role in the development of the visual system. Luebbering N, et al. PLoS One, 2013. PMID 24146926, Free PMC Article
    5. A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT. Gwack Y, et al. Nature, 2006 Jun 1. PMID 16511445

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    mobile_element

    • Loc: c1228455-1228012 mobile_element_type = transposon:INE-1{}3975

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine/tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine/tyrosine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Dual-specificity tyrosine phosphorylation-regulated kinase 3
    Names
    CG40478-PA
    CG40478-PC
    CG40478-PE
    Dyrk3-PA
    Dyrk3-PC
    Dyrk3-PE
    unknown-telomeric-protein-gene
    NP_001033810.1
    NP_001033812.1
    NP_001033814.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004353.4 Reference assembly

      Range
      1225089..1230713 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001038725.2 → NP_001033814.1  Dual-specificity tyrosine phosphorylation-regulated kinase 3, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001033814.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V144, P83102, Q2PDL5, Q5LJP2, Q8MT39, Q9Y1N4
      Conserved Domains (2) summary
      smart00220
      Location:276 → 589
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14224
      Location:211 → 589
      PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3

    2. NM_001038721.2 → NP_001033810.1  Dual-specificity tyrosine phosphorylation-regulated kinase 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001033810.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V144, P83102, Q2PDL5, Q5LJP2, Q8MT39, Q9Y1N4
      Conserved Domains (2) summary
      smart00220
      Location:276 → 589
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14224
      Location:211 → 589
      PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3

    3. NM_001038723.2 → NP_001033812.1  Dual-specificity tyrosine phosphorylation-regulated kinase 3, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001033812.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V144, P83102, Q2PDL5, Q5LJP2, Q8MT39, Q9Y1N4
      Conserved Domains (2) summary
      smart00220
      Location:276 → 589
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14224
      Location:211 → 589
      PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P83102.3 P83102

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