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    Naxd NAD(P)HX dehydratase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40085, updated on 4-Jan-2025

    Summary

    Official Symbol
    Naxdprovided by FlyBase
    Official Full Name
    NAD(P)HX dehydrataseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036848
    Locus tag
    Dmel_CG10424
    See related
    AllianceGenome:FB:FBgn0036848
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10424; Dmel\CG10424
    Summary
    Predicted to enable ATP-dependent NAD(P)H-hydrate dehydratase activity. Predicted to be involved in metabolite repair. Predicted to be located in cytosol and mitochondrion. Is expressed in adult head; embryonic/larval midgut; and organism. Orthologous to human NAXD (NAD(P)HX dehydratase). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
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    Genomic context

    See Naxd in Genome Data Viewer
    Location:
    75F7-75F7; 3-45 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19096399..19097709, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19089499..19090809, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Misexpression suppressor of ras 6 Neighboring gene Canopy b Neighboring gene uncharacterized protein Neighboring gene Gemin 2

    Genomic regions, transcripts, and products

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP-dependent NAD(P)H-hydrate dehydratase activity  
    enables ATP-dependent NAD(P)H-hydrate dehydratase activity  
    enables hydro-lyase activity  
    Process Evidence Code Pubs
    involved_in metabolite repair  
    involved_in metabolite repair  
    Component Evidence Code Pubs
    located_in cytosol  
    located_in mitochondrion  

    General protein information

    Preferred Names
    NAD(P)HX dehydratase
    Names
    CG10424-PA
    Naxd-PA
    NP_649090.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      19096399..19097709 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140833.3 → NP_649090.1  NAD(P)HX dehydratase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649090.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VVW8
      Related
      FBpp0074800
      Conserved Domains (1) summary
      cd01171
      Location:28 → 287
      YXKO-related; B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.
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