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    hlk hulk [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 46017, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hlkprovided by FlyBase
    Official Full Name
    hulkprovided by FlyBase
    Primary source
    FLYBASE:FBgn0010482
    Locus tag
    Dmel_CG9432
    See related
    AllianceGenome:FB:FBgn0010482
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG30444; CG9432; CG9435; Dmel\CG9432; l(2)01289
    Summary
    Is expressed in several structures, including adult fat body; adult head; adult heart; embryonic/larval cuticle; and spermatozoon. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See hlk in Genome Data Viewer
    Location:
    42C6-42C7; 2-55 cM
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6721101..6740672, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2608606..2628177, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Zinc/iron regulated transporter-related protein 42C.1 Neighboring gene Zinc/iron regulated transporter-related protein 42C.2 Neighboring gene phtf Neighboring gene Methylcrotonoyl-CoA carboxylase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pupal behavior emerges from unstructured muscle activity in response to neuromodulation in Drosophila. Elliott AD, et al. Elife, 2021 Jul 8. PMID 34236312, Free PMC Article
    2. Molecular and cytological analysis of widely-used Gal4 driver lines for Drosophila neurobiology. Ogienko AA, et al. BMC Genet, 2020 Oct 22. PMID 33092520, Free PMC Article
    3. Genetic dissociation of ethanol sensitivity and memory formation in Drosophila melanogaster. LaFerriere H, et al. Genetics, 2008 Apr. PMID 18430923, Free PMC Article
    4. Effects of tethering HP1 to euchromatic regions of the Drosophila genome. Li Y, et al. Development, 2003 May. PMID 12642487
    5. Fenton chemistry and oxidative stress mediate the toxicity of the beta-amyloid peptide in a Drosophila model of Alzheimer's disease. Rival T, et al. Eur J Neurosci, 2009 Apr. PMID 19519625, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    hulk
    Names
    CG9432-PA
    CG9432-PB
    CG9432-PF
    CG9432-PG
    CG9432-PH
    CG9432-PJ
    CG9432-PK
    CG9432-PL
    CG9432-PM
    Fusion-2
    Fusion2
    hlk-PA
    hlk-PB
    hlk-PF
    hlk-PG
    hlk-PH
    hlk-PJ
    hlk-PK
    hlk-PL
    hlk-PM
    lethal (2) 01289

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      6721101..6740672 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001043009.3 → NP_001036474.2  hulk, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036474.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E9N3
      Conserved Domains (3) summary
      cd02947
      Location:487 → 556
      TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
      cd02961
      Location:266 → 363
      PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
      cl00388
      Location:155 → 253
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    2. NM_001169595.2 → NP_001163066.1  hulk, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163066.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JGY5
      Conserved Domains (5) summary
      cd02947
      Location:1019 → 1088
      TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
      cd02961
      Location:798 → 895
      PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
      PTZ00102
      Location:9 → 216
      PTZ00102; disulphide isomerase; Provisional
      TIGR01130
      Location:369 → 585
      ER_PDI_fam; protein disulfide isomerase, eukaryotic
      pfam13848
      Location:179 → 358
      Thioredoxin_6; Thioredoxin-like domain

    3. NM_001043010.4 → NP_001036475.3  hulk, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036475.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E9N2
      Conserved Domains (4) summary
      cd02961
      Location:1117 → 1214
      PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
      PTZ00102
      Location:9 → 213
      PTZ00102; disulphide isomerase; Provisional
      TIGR01130
      Location:688 → 904
      ER_PDI_fam; protein disulfide isomerase, eukaryotic
      pfam13848
      Location:498 → 677
      Thioredoxin_6; Thioredoxin-like domain

    4. NM_165485.3 → NP_724492.1  hulk, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724492.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V9A9
      Related
      FBpp0085470
      Conserved Domains (4) summary
      cd02947
      Location:1350 → 1419
      TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
      cd02961
      Location:1129 → 1226
      PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
      TIGR01130
      Location:700 → 916
      ER_PDI_fam; protein disulfide isomerase, eukaryotic
      pfam13848
      Location:510 → 689
      Thioredoxin_6; Thioredoxin-like domain

    5. NM_001169594.2 → NP_001163065.1  hulk, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163065.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JGY6
      Conserved Domains (4) summary
      cd02947
      Location:1433 → 1502
      TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
      cd02961
      Location:1129 → 1226
      PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
      TIGR01130
      Location:700 → 916
      ER_PDI_fam; protein disulfide isomerase, eukaryotic
      pfam13848
      Location:510 → 689
      Thioredoxin_6; Thioredoxin-like domain

    6. NM_143769.6 → NP_652026.2  hulk, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652026.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z6P2, Q7KJC0
      Related
      FBpp0085469
      Conserved Domains (3) summary
      cd02961
      Location:50 → 145
      PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
      pfam13848
      Location:179 → 358
      Thioredoxin_6; Thioredoxin-like domain
      cl00388
      Location:264 → 358
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    7. NM_001259223.2 → NP_001246152.1  hulk, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246152.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K819, Q7KJC0
      Conserved Domains (3) summary
      cd02961
      Location:50 → 145
      PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
      pfam13848
      Location:179 → 358
      Thioredoxin_6; Thioredoxin-like domain
      cl00388
      Location:264 → 358
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    8. NM_001169593.2 → NP_001163064.1  hulk, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163064.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JGY7
      Conserved Domains (3) summary
      cd02961
      Location:50 → 145
      PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
      pfam13848
      Location:179 → 358
      Thioredoxin_6; Thioredoxin-like domain
      cl00388
      Location:264 → 358
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    9. NM_001259224.2 → NP_001246153.1  hulk, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246153.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7H1
      Conserved Domains (3) summary
      cd02961
      Location:50 → 145
      PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
      pfam13848
      Location:179 → 358
      Thioredoxin_6; Thioredoxin-like domain
      cl00388
      Location:264 → 358
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K7H1 A0A0B4K7H1
    A0A0B4K819 A0A0B4K819
    A1Z6P2 A1Z6P2
    E1JGY5 E1JGY5
    E1JGY6 E1JGY6
    E1JGY7 E1JGY7
    Q0E9N2 Q0E9N2
    Q0E9N3 Q0E9N3
    Q7KJB9 Q7KJB9
    Q7KJC0 Q7KJC0
    Q7KJC1 Q7KJC1
    Q8IGT3 Q8IGT3
    Q9N6X2 Q9N6X2
    Q9V9A9 Q9V9A9

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