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    LUBEL Linear Ubiquitin E3 ligase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33950, updated on 9-Dec-2024

    Summary

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    Official Symbol
    LUBELprovided by FlyBase
    Official Full Name
    Linear Ubiquitin E3 ligaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031857
    Locus tag
    Dmel_CG11321
    See related
    AllianceGenome:FB:FBgn0031857
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AAF52435.2; CG11321; Dmel\CG11321; lubel; Lubel
    Summary
    Enables linear polyubiquitin binding activity; polyubiquitin modification-dependent protein binding activity; and ubiquitin protein ligase activity. Involved in several processes, including heat acclimation; positive regulation of peptidoglycan recognition protein signaling pathway; and protein linear polyubiquitination. Predicted to be part of LUBAC complex. Is expressed in dorsal pharyngeal muscle cell; larval somatic muscle cell; and somatic muscle primordium. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human RNF31 (ring finger protein 31). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See LUBEL in Genome Data Viewer
    Location:
    27B1-27B1; 2-22 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6759829..6772755, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6759829..6772755, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene meng-po Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene nervana 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neuroprotective effects of linear ubiquitin E3 ligase against aging-induced DNA damage and amyloid β neurotoxicity in the brain of Drosophila melanogaster. Choi B, et al. Biochem Biophys Res Commun, 2022 Dec 31. PMID 36403483
    2. The linear ubiquitin E3 ligase-Relish pathway is involved in the regulation of proteostasis in Drosophila muscle during aging. Lee B, et al. Biochem Biophys Res Commun, 2021 Apr 23. PMID 33706102
    3. The ring between ring fingers (RBR) protein family. Eisenhaber B, et al. Genome Biol, 2007. PMID 17367545, Free PMC Article
    4. Linear ubiquitination by LUBEL has a role in Drosophila heat stress response. Asaoka T, et al. EMBO Rep, 2016 Nov. PMID 27702987, Free PMC Article
    5. M1-linked ubiquitination facilitates NF-κB activation and survival during sterile inflammation. Aalto A, et al. FEBS J, 2022 Sep. PMID 35263507, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables K48-linked polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables K48-linked polyubiquitin modification-dependent protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables K63-linked polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables K63-linked polyubiquitin modification-dependent protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables linear polyubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables linear polyubiquitin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heat acclimation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of peptidoglycan recognition protein signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein linear polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein linear polyubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of LUBAC complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    linear ubiquitin E3 ligase
    Names
    CG11321-PC
    CG11321-PD
    CG11321-PE
    CG11321-PF
    CG11321-PG
    CG11321-PH
    CG11321-PI
    CG11321-PJ
    CG11321-PK
    LUBEL-PC
    LUBEL-PD
    LUBEL-PE
    LUBEL-PF
    LUBEL-PG
    LUBEL-PH
    LUBEL-PI
    LUBEL-PJ
    LUBEL-PK

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6759829..6772755 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273228.2 → NP_001260157.1  linear ubiquitin E3 ligase, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260157.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PB55
      Conserved Domains (8) summary
      pfam09528
      Location:1298 → 1849
      Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
      smart00547
      Location:737 → 761
      ZnF_RBZ; Zinc finger domain
      smart00647
      Location:2557 → 2619
      IBR; In Between Ring fingers
      PRK01741
      Location:1164 → 1361
      PRK01741; cell division protein ZipA; Provisional
      sd00029
      Location:738 → 757
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam01485
      Location:2661 → 2683
      IBR; IBR domain, a half RING-finger domain
      pfam13923
      Location:2473 → 2521
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)
      pfam16678
      Location:1036 → 1177
      HOIP-UBA; UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase

    2. NM_001273230.2 → NP_001260159.1  linear ubiquitin E3 ligase, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260159.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCS0
      Conserved Domains (9) summary
      pfam09528
      Location:1286 → 1837
      Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
      smart00547
      Location:684 → 708
      ZnF_RBZ; Zinc finger domain
      smart00647
      Location:2545 → 2607
      IBR; In Between Ring fingers
      PRK01741
      Location:1146 → 1349
      PRK01741; cell division protein ZipA; Provisional
      sd00029
      Location:685 → 704
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam01485
      Location:2649 → 2671
      IBR; IBR domain, a half RING-finger domain
      pfam13923
      Location:2461 → 2509
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)
      pfam16678
      Location:983 → 1131
      HOIP-UBA; UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase
      cl21463
      Location:1076 → 1129
      UBA_like_SF; UBA domain-like superfamily

    3. NM_001273231.2 → NP_001260160.1  linear ubiquitin E3 ligase, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260160.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCD7
      Conserved Domains (8) summary
      pfam09528
      Location:1245 → 1796
      Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
      smart00547
      Location:684 → 708
      ZnF_RBZ; Zinc finger domain
      smart00647
      Location:2504 → 2566
      IBR; In Between Ring fingers
      PRK01741
      Location:1111 → 1308
      PRK01741; cell division protein ZipA; Provisional
      sd00029
      Location:685 → 704
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam01485
      Location:2608 → 2630
      IBR; IBR domain, a half RING-finger domain
      pfam13923
      Location:2420 → 2468
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)
      pfam16678
      Location:983 → 1124
      HOIP-UBA; UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase

    4. NM_164709.4 → NP_723214.2  linear ubiquitin E3 ligase, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723214.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9PB55, M9PCD7, M9PCS0, Q8IPJ3, Q9VM88
      Conserved Domains (12) summary
      smart00547
      Location:737 → 761
      ZnF_RBZ; Zinc finger domain
      smart00647
      Location:2598 → 2660
      IBR; In Between Ring fingers
      PRK01741
      Location:1199 → 1402
      PRK01741; cell division protein ZipA; Provisional
      PRK10811
      Location:1482 → 1771
      rne; ribonuclease E; Reviewed
      sd00029
      Location:738 → 757
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam09606
      Location:336 → 483
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd16551
      Location:2513 → 2563
      RING-HC_RNF169; RING finger, HC subclass, found in RING finger protein 169 (RNF169) and similar proteins
      cd19815
      Location:89 → 132
      Bbox1_HOIP; B-box-type 1 zinc finger found in HOIL-1-interacting protein (HOIP) and similar proteins
      pfam01485
      Location:2690 → 2724
      IBR; IBR domain, a half RING-finger domain
      pfam16678
      Location:1036 → 1184
      HOIP-UBA; HOIP UBA domain pair
      pfam18091
      Location:2760 → 2858
      E3_UbLigase_RBR; E3 Ubiquitin Ligase RBR C-terminal domain
      NF033804
      Location:2159 → 2307
      Streccoc_I_II; antigen I/II family LPXTG-anchored adhesin

    5. NM_001273229.2 → NP_001260158.1  linear ubiquitin E3 ligase, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260158.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PC77
      Conserved Domains (2) summary
      smart00547
      Location:737 → 761
      ZnF_RBZ; Zinc finger domain
      sd00029
      Location:738 → 757
      zf-RanBP2; RanBP2-type Zn finger [structural motif]

    6. NM_001273227.1 → NP_001260156.1  linear ubiquitin E3 ligase, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260156.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VM88
      Conserved Domains (2) summary
      smart00547
      Location:684 → 708
      ZnF_RBZ; Zinc finger domain
      sd00029
      Location:685 → 704
      zf-RanBP2; RanBP2-type Zn finger [structural motif]

    7. NM_135228.4 → NP_609072.2  linear ubiquitin E3 ligase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609072.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VM88
      Conserved Domains (2) summary
      smart00547
      Location:684 → 708
      ZnF_RBZ; Zinc finger domain
      sd00029
      Location:685 → 704
      zf-RanBP2; RanBP2-type Zn finger [structural motif]

    8. NM_001273232.2 → NP_001260161.1  linear ubiquitin E3 ligase, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260161.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A9UN74, E1JHA3
      Conserved Domains (1) summary
      pfam01485
      Location:60 → 123
      IBR; IBR domain

    9. NM_001169425.2 → NP_001162896.1  linear ubiquitin E3 ligase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162896.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A9UN74, E1JHA3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JHA3 E1JHA3
    M9PC77 M9PC77
    Q86P90 Q86P90
    Q8IPJ3.2 Q8IPJ3

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