nxf2 nuclear RNA export factor 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: nxf2provided by FlyBase
Official Full Name: nuclear RNA export factor 2provided by FlyBase
Primary source: FLYBASE:FBgn0036640
Locus tag: Dmel_CG4118
See related: AllianceGenome:FB:FBgn0036640
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG4118; Dmel\CG4118; dNxf2; Nxf2; NXF2
Summary: Enables chromatin-protein adaptor activity; single-stranded RNA binding activity; and transcription corepressor activity. Involved in piRNA-mediated retrotransposon silencing by heterochromatin formation and protein localization to nuclear periphery. Located in cytoplasm and nucleoplasm. Part of RNA polymerase II transcription repressor complex. Is expressed in several structures, including dorsal ectoderm; dorsal epidermis primordium; mesoderm; somatic muscle primordium; and ventral ectoderm. Orthologous to human NXF3 (nuclear RNA export factor 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (16576859..16580306, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (16569959..16573406, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin-protein adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables single-stranded RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription corepressor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in poly(A)+ mRNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to nuclear periphery	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transposable element silencing by piRNA-mediated heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription repressor complex	IPI Inferred from Physical Interaction more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription repressor complex	IDA Inferred from Direct Assay more info	PubMed

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