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    CG3301 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42528, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG3301provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038878
    Locus tag
    Dmel_CG3301
    See related
    AllianceGenome:FB:FBgn0038878
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG3301; FOHSDR
    Summary
    Predicted to enable 3-keto sterol reductase activity and steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Is expressed in adult head. Orthologous to human DHRS11 (dehydrogenase/reductase 11). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG3301 in Genome Data Viewer
    Location:
    93D2-93D2; 3-71 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21274243..21276249, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (17099965..17101971, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Adaptor Protein complex 2, sigma subunit Neighboring gene uncharacterized protein Neighboring gene Isopentenyl-diphosphate delta isomerase Neighboring gene SIFamide receptor Neighboring gene uncharacterized protein Neighboring gene Heat shock RNA omega Neighboring gene mir-4951 stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inhibition of mevalonate pathway by macrophage-specific delivery of atorvastatin prevents their pro-inflammatory polarisation. Krejčová G, et al. Insect Mol Biol, 2024 Aug. PMID 38367277
    2. PRE-mediated bypass of two Su(Hw) insulators targets PcG proteins to a downstream promoter. Comet I, et al. Dev Cell, 2006 Jul. PMID 16824958
    3. Functional analysis of PGRP-LA in Drosophila immunity. Gendrin M, et al. PLoS One, 2013. PMID 23922788, Free PMC Article
    4. Genome-wide transcription profile of field- and laboratory-selected dichlorodiphenyltrichloroethane (DDT)-resistant Drosophila. Pedra JH, et al. Proc Natl Acad Sci U S A, 2004 May 4. PMID 15118106, Free PMC Article
    5. Intestinal response to dietary manganese depletion in Drosophila. Vásquez-Procopio J, et al. Metallomics, 2020 Feb 1. PMID 31799578

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 17-beta-hydroxysteroid dehydrogenase (NADP+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables 17-beta-ketosteroid reductase (NADPH) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables 3-keto sterol reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG3301-PA
    CG3301-PB
    CG3301-PC
    NP_001287440.1
    NP_650964.1
    NP_732612.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      21274243..21276249 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169954.2 → NP_732612.1  uncharacterized protein Dmel_CG3301, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732612.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VDC0
      Related
      FBpp0083500
      Conserved Domains (2) summary
      COG4221
      Location:1 → 250
      YdfG; NADP-dependent 3-hydroxy acid dehydrogenase YdfG [Energy production and conversion]
      cl21454
      Location:1 → 245
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. NM_142707.3 → NP_650964.1  uncharacterized protein Dmel_CG3301, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650964.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VDC0
      Related
      FBpp0083499
      Conserved Domains (2) summary
      COG4221
      Location:1 → 250
      YdfG; NADP-dependent 3-hydroxy acid dehydrogenase YdfG [Energy production and conversion]
      cl21454
      Location:1 → 245
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    3. NM_001300511.1 → NP_001287440.1  uncharacterized protein Dmel_CG3301, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287440.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VDC0
      Conserved Domains (2) summary
      COG4221
      Location:1 → 250
      YdfG; NADP-dependent 3-hydroxy acid dehydrogenase YdfG [Energy production and conversion]
      cl21454
      Location:1 → 245
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VDC0 Q9VDC0

    Gene LinkOut

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