U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CG31515 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 326147, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CG31515provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0051515
    Locus tag
    Dmel_CG31515
    See related
    AllianceGenome:FB:FBgn0051515
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG31515
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Involved in sexual reproduction. Located in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including factor VIII deficiency; leukemia (multiple); osteonecrosis; thrombophilia (multiple); and toxic shock syndrome. Orthologous to human TFPI (tissue factor pathway inhibitor) and TFPI2 (tissue factor pathway inhibitor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CG31515 in Genome Data Viewer
    Location:
    94F1-94F1; 3-79 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23388373..23388898, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19214095..19214620, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43387 Neighboring gene long non-coding RNA:CR44323

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Identification and function of proteolysis regulators in seminal fluid. Laflamme BA, et al. Mol Reprod Dev, 2013 Feb. PMID 23109270, Free PMC Article
    2. Proteomics reveals novel Drosophila seminal fluid proteins transferred at mating. Findlay GD, et al. PLoS Biol, 2008 Jul 29. PMID 18666829, Free PMC Article
    3. Transcriptomic analysis of inbreeding depression in cold-sensitive Drosophila melanogaster shows upregulation of the immune response. Vermeulen CJ, et al. J Evol Biol, 2013 Sep. PMID 23944235
    4. mRNA-Associated Processes and Their Influence on Exon-Intron Structure in Drosophila melanogaster. Lepennetier G, et al. G3 (Bethesda), 2016 Jun 1. PMID 27172210, Free PMC Article
    5. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in sexual reproduction HEP PubMed 
    Component Evidence Code Pubs
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    uncharacterized protein
    Names
    CG31515-PB

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      23388373..23388898 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170074.2 → NP_732865.2  uncharacterized protein Dmel_CG31515 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732865.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DMT5, Q9VCM5
      Conserved Domains (1) summary
      smart00131
      Location:47 → 97
      KU; BPTI/Kunitz family of serine protease inhibitors
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VCM5 Q9VCM5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools