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    sing singles bar [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32644, updated on 17-Dec-2024

    Summary

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    Official Symbol
    singprovided by FlyBase
    Official Full Name
    singles barprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261245
    Locus tag
    Dmel_CG13011
    See related
    AllianceGenome:FB:FBgn0261245
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13011; Dmel\CG13011; Sing; singles-bar
    Summary
    Involved in adult somatic muscle development and myoblast fusion. Predicted to be active in membrane. Is expressed in several structures, including larval muscle system; muscle cell; myoblast; somatic mesoderm; and somatic muscle primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See sing in Genome Data Viewer
    Location:
    15A1-15A1; 1-55 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16679297..16681784)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16573330..16575817)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Abnormal X segregation Neighboring gene Septin 4 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of singles bar as a direct transcriptional target of Drosophila Myocyte enhancer factor-2 and a regulator of adult myoblast fusion. Brunetti TM, et al. Dev Biol, 2015 May 15. PMID 25797154, Free PMC Article
    2. Surface apposition and multiple cell contacts promote myoblast fusion in Drosophila flight muscles. Dhanyasi N, et al. J Cell Biol, 2015 Oct 12. PMID 26459604, Free PMC Article
    3. Differential requirements for Myocyte Enhancer Factor-2 during adult myogenesis in Drosophila. Bryantsev AL, et al. Dev Biol, 2012 Jan 15. PMID 22008792, Free PMC Article
    4. The MARVEL domain protein, Singles Bar, is required for progression past the pre-fusion complex stage of myoblast fusion. Estrada B, et al. Dev Biol, 2007 Jul 15. PMID 17537424, Free PMC Article
    5. Drosophila dumbfounded: a myoblast attractant essential for fusion. Ruiz-Gómez M, et al. Cell, 2000 Jul 21. PMID 10943839

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. lack of sing expression resulted in adult lethality and muscle loss, due to a failure of fusion during the pupal stage.
      Title: Identification of singles bar as a direct transcriptional target of Drosophila Myocyte enhancer factor-2 and a regulator of adult myoblast fusion.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in adult somatic muscle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in myoblast fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    singles bar
    Names
    CG13011-PA
    sing
    sing-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16679297..16681784
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132918.2 → NP_573146.1  singles bar [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573146.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G2J5W8, Q9VXD1
      Related
      FBpp0074092
      Conserved Domains (1) summary
      pfam01284
      Location:30 → 167
      MARVEL; Membrane-associating domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VXD1.1 Q9VXD1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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