ATPsynD ATP synthase, subunit D [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ATPsynDprovided by FlyBase
Official Full Name: ATP synthase, subunit Dprovided by FlyBase
Primary source: FLYBASE:FBgn0016120
Locus tag: Dmel_CG6030
See related: AllianceGenome:FB:FBgn0016120
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: ATP syn-d; ATPQ; ATPsyn-d; ATPsyn-D; ATPsyn-delta; CG6030; Dmel\CG6030
Summary: Predicted to enable proton transmembrane transporter activity. Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Involved in several processes, including ATP metabolic process; determination of adult lifespan; and negative regulation of intracellular signal transduction. Located in mitochondrion. Is expressed in several structures, including Malpighian tubule primordium; adult head; embryonic/larval midgut primordium; larval somatic muscle cell; and trunk visceral muscle primordium. Orthologous to human ATP5PD (ATP synthase peripheral stalk subunit d). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (19095000..19096271)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (14920722..14921993)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables proton transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
contributes_to proton-transporting ATP synthase activity, rotational mechanism	IBA Inferred from Biological aspect of Ancestor more info
contributes_to proton-transporting ATP synthase activity, rotational mechanism	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in ATP metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of TOR signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proton motive force-driven ATP synthesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proton motive force-driven ATP synthesis	IEA Inferred from Electronic Annotation more info
involved_in proton motive force-driven ATP synthesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in proton transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of mitochondrial membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	HDA more info	PubMed
part_of proton-transporting ATP synthase complex, coupling factor F(o)	IEA Inferred from Electronic Annotation more info
part_of proton-transporting ATP synthase, stator stalk	ISS Inferred from Sequence or Structural Similarity more info

Names: ATP synthase D chain; ATP synthase chain D; ATP synthase subunits d; ATP synthase, subunit d; ATP synthase,d; ATPase synthase, subunit d; ATPsyn-d; ATPsynD-PA; ATPsynD-PB; ATPsynD-PC; CG6030-PA; CG6030-PB; CG6030-PC; F0/F1 ATP synthase D

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The following sections contain reference sequences that belong to a specific genome build. Explain