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    ScsbetaG Succinyl-coenzyme A synthetase beta subunit, GDP-forming [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44001, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ScsbetaGprovided by FlyBase
    Official Full Name
    Succinyl-coenzyme A synthetase beta subunit, GDP-formingprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029118
    Locus tag
    Dmel_CG10622
    See related
    AllianceGenome:FB:FBgn0029118
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    142911_at; CG10622; Dmel\CG10622; G-Sbeta; sucb; sucB; Sucb; SucB
    Summary
    Predicted to enable succinate-CoA ligase (GDP-forming) activity. Predicted to be involved in succinyl-CoA metabolic process and tricarboxylic acid cycle. Predicted to be part of succinate-CoA ligase complex (GDP-forming). Predicted to be active in mitochondrion. Is expressed in several structures, including Malpighian tubule primordium; adult head; embryonic/larval midgut; embryonic/larval midgut primordium; and hindgut proper primordium. Orthologous to human SUCLG2 (succinate-CoA ligase GDP-forming subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ScsbetaG in Genome Data Viewer
    Location:
    64D3-64D3; 3-14 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5561701..5563691, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5554801..5556791, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene farmer Neighboring gene sinuous Neighboring gene severas Neighboring gene bc10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Krebs Cycle Component Limits Caspase Activation Rate through Mitochondrial Surface Restriction of CRL Activation. Aram L, et al. Dev Cell, 2016 Apr 4. PMID 27052834
    2. Widespread polymorphism in the positions of stop codons in Drosophila melanogaster. Lee YC, et al. Genome Biol Evol, 2012. PMID 22051795, Free PMC Article
    3. The oxoglutarate dehydrogenase complex is involved in myofibril growth and Z-disc assembly in Drosophila. González Morales N, et al. J Cell Sci, 2023 Jul 1. PMID 37272588, Free PMC Article
    4. Pleiotropic fitness effects of the Tre1-Gr5a region in Drosophila melanogaster. Rollmann SM, et al. Nat Genet, 2006 Jul. PMID 16783380
    5. Sinuous is a Drosophila claudin required for septate junction organization and epithelial tube size control. Wu VM, et al. J Cell Biol, 2004 Jan 19. PMID 14734539, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables succinate-CoA ligase (ADP-forming) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables succinate-CoA ligase (GDP-forming) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables succinate-CoA ligase (GDP-forming) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in succinyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in succinyl-CoA metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of succinate-CoA ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of succinate-CoA ligase complex (GDP-forming) ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Succinyl-coenzyme A synthetase beta subunit, GDP-forming
    Names
    CG10622-PA
    CG10622-PC
    GTP-specific SCSbeta
    GTP-specific form of the succinyl-CoA synthetase beta subunit
    ScsbetaG-PA
    ScsbetaG-PC
    sucb
    succinyl CoA synthetase
    succinyl coenzyme A synthetase GDP-forming beta subunit
    NP_001286941.1
    NP_651963.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      5561701..5563691 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143706.5 → NP_651963.1  Succinyl-coenzyme A synthetase beta subunit, GDP-forming, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651963.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V470
      Related
      FBpp0076840
      Conserved Domains (3) summary
      PRK00696
      Location:24 → 416
      sucC; succinyl-CoA synthetase subunit beta; Provisional
      pfam00549
      Location:292 → 412
      Ligase_CoA; CoA-ligase
      cl17255
      Location:24 → 232
      ATP-grasp_4; ATP-grasp domain

    2. NM_001300012.1 → NP_001286941.1  Succinyl-coenzyme A synthetase beta subunit, GDP-forming, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286941.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V470
      Conserved Domains (3) summary
      PRK00696
      Location:24 → 416
      sucC; succinyl-CoA synthetase subunit beta; Provisional
      pfam00549
      Location:292 → 412
      Ligase_CoA; CoA-ligase
      cl17255
      Location:24 → 232
      ATP-grasp_4; ATP-grasp domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V470 Q9V470

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