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    Dgkepsilon Diacyl glycerol kinase epsilon [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36408, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dgkepsilonprovided by FlyBase
    Official Full Name
    Diacyl glycerol kinase epsilonprovided by FlyBase
    Primary source
    FLYBASE:FBgn0020930
    Locus tag
    Dmel_CG8657
    See related
    AllianceGenome:FB:FBgn0020930
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8657; DGKe; dgkepsilon; DGKepsilon; Dmel\CG8657
    Summary
    Enables ATP-dependent diacylglycerol kinase activity. Predicted to be involved in glycerolipid metabolic process and intracellular signal transduction. Predicted to be active in membrane. Is expressed in several structures, including adult head; germ layer; germline cell; imaginal disc; and midgut primordium. Human ortholog(s) of this gene implicated in nephrotic syndrome type 7. Orthologous to human DGKE (diacylglycerol kinase epsilon). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dgkepsilon in Genome Data Viewer
    Location:
    49C2-49C2; 2-67 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12757546..12759724)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8645051..8647229)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Tafazzin Neighboring gene mitochondrial ribosomal protein L18 Neighboring gene oxen Neighboring gene Nascent polypeptide associated complex protein alpha subunit Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45266

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular analysis of a novel Drosophila diacylglycerol kinase, DGKepsilon. Frolov MV, et al. Biochim Biophys Acta, 2001 Apr 23. PMID 11336805
    2. Inhibition of lipid signaling enzyme diacylglycerol kinase epsilon attenuates mutant huntingtin toxicity. Zhang N, et al. J Biol Chem, 2012 Jun 15. PMID 22511757, Free PMC Article
    3. The Drosophila MOS ortholog is not essential for meiosis. Ivanovska I, et al. Curr Biol, 2004 Jan 6. PMID 14711418
    4. The autophagy protein Def8 is altered in Alzheimer's disease and Aβ42-expressing Drosophila brains. Oyarce-Pezoa S, et al. Sci Rep, 2023 Oct 10. PMID 37816871, Free PMC Article
    5. A Drosophila chemical screen reveals synergistic effect of MEK and DGKα inhibition in Ras-driven cancer. La Marca JE, et al. Dis Model Mech, 2023 Mar 1. PMID 36861754, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP-dependent diacylglycerol kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent diacylglycerol kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP-dependent diacylglycerol kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycerolipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    diacyl glycerol kinase epsilon
    Names
    CG8657-PA
    CG8657-PB
    Dgkepsilon-PA
    Dgkepsilon-PB
    diacylglycerol kinase epsilon
    NP_001286362.1
    NP_725228.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12757546..12759724
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165949.2 → NP_725228.1  diacyl glycerol kinase epsilon, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725228.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F3YD90, O44334, Q7K579
      Related
      FBpp0086966
      Conserved Domains (4) summary
      smart00046
      Location:207 → 331
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG1597
      Location:207 → 519
      LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
      pfam00130
      Location:108 → 165
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00609
      Location:355 → 510
      DAGK_acc; Diacylglycerol kinase accessory domain

    2. NM_001299433.1 → NP_001286362.1  diacyl glycerol kinase epsilon, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286362.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F3YD90, O44334, Q7K579
      Conserved Domains (4) summary
      smart00046
      Location:207 → 331
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG1597
      Location:207 → 519
      LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
      pfam00130
      Location:108 → 165
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00609
      Location:355 → 510
      DAGK_acc; Diacylglycerol kinase accessory domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O44334 O44334
    Q7K579 Q7K579

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