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    ohgt ohgata [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41230, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ohgtprovided by FlyBase
    Official Full Name
    ohgataprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037780
    Locus tag
    Dmel_CG3925
    See related
    AllianceGenome:FB:FBgn0037780
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3925; Crbn; Dmel\CG3925
    Summary
    Involved in positive regulation of Wnt signaling pathway and positive regulation of neuromuscular synaptic transmission. Located in nucleus. Is expressed in fat body and organism. Used to study autosomal recessive intellectual developmental disorder. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 2. Orthologous to human CRBN (cereblon). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ohgt in Genome Data Viewer
    Location:
    85F8-85F8; 3-49 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (10049199..10051527)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5874921..5877249)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mitochondrial transcription factor B2 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44192 Neighboring gene fancl Neighboring gene Niemann-Pick type C-2e Neighboring gene Niemann-Pick type C-2d

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cereblon Maintains Synaptic and Cognitive Function by Regulating BK Channel. Choi TY, et al. J Neurosci, 2018 Apr 4. PMID 29530986, Free PMC Article
    2. Ohgata, the Single Drosophila Ortholog of Human Cereblon, Regulates Insulin Signaling-dependent Organismic Growth. Wakabayashi S, et al. J Biol Chem, 2016 Nov 25. PMID 27702999, Free PMC Article
    3. The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling. Shen C, et al. Nat Commun, 2021 Sep 6. PMID 34489457, Free PMC Article
    4. Drosophila MICAL regulates myofilament organization and synaptic structure. Beuchle D, et al. Mech Dev, 2007 May. PMID 17350233
    5. Identification of seven genes essential for male fertility through a genome-wide association study of non-obstructive azoospermia and RNA interference-mediated large-scale functional screening in Drosophila. Yu J, et al. Hum Mol Genet, 2015 Mar 1. PMID 25361961

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of neuromuscular synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul4A-RING E3 ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    ohgata
    Names
    CG3925-PA
    ohgt-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      10049199..10051527
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141716.3 → NP_649973.1  ohgata [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649973.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VH35, Q9VH36
      Related
      FBpp0081652
      Conserved Domains (2) summary
      PHA02664
      Location:35 → 109
      PHA02664; hypothetical protein; Provisional
      cd15777
      Location:453 → 555
      CRBN_C_like; Thalidomide-binding C-terminal domain of cereblon (CRBN) and similar protein domains
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VH36.1 Q9VH36

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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