nrv2 nervana 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: nrv2provided by FlyBase
Official Full Name: nervana 2provided by FlyBase
Primary source: FLYBASE:FBgn0015777
Locus tag: Dmel_CG9261
See related: AllianceGenome:FB:FBgn0015777
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 42kDa; CG9261; Dmel\CG9261; ecta; K-ATPase; l(2)k04223; l(2)k13315; l(2)SH0329; l(2)SH2 0329; Na; NaK ATPase; Na[+]/K[+] ATPase; Na[+]/K[+]-ATPase; Na[+]/K[+]ATPase; NEST:bs13c10; Nrv; Nrv2; nrv2.2; Nrv2.2
Summary: Enables ATPase activator activity. Involved in several processes, including cell adhesion involved in heart morphogenesis; establishment of glial blood-brain barrier; and regulation of tube size, open tracheal system. Located in axon; plasma membrane; and septate junction. Part of sodium:potassium-exchanging ATPase complex. Is expressed in several structures, including ganglia; glial cell; head epidermis primordium; organism subdivision; and synaptic neuropil domain. Used to study epilepsy. Human ortholog(s) of this gene implicated in atrophic gastritis; autoimmune gastritis; essential hypertension; and stomach cancer. Orthologous to several human genes including ATP1B4 (ATPase Na+/K+ transporting family member beta 4); ATP1B1 (ATPase Na+/K+ transporting subunit beta 1); and ATP1B2 (ATPase Na+/K+ transporting subunit beta 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 27B1-27B2; 2-22 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (6789770..6798862, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (6789770..6798862, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knocking down nrv2 in scolopale cells blocked Nrv2 expression, reduced ATPalpha expression in the scolopale cells, and caused almost complete deafness.
Title: Cell-type-specific roles of Na+/K+ ATPase subunits in Drosophila auditory mechanosensation.
Gene expression of the beta-subunit of Na+/K+-ATPase were slightly clock-controlled.
Title: Cyclical expression of Na+/K+-ATPase in the visual system of Drosophila melanogaster.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATPase activator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion involved in heart morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of glial blood-brain barrier	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular potassium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular sodium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic cation transport	IDA Inferred from Direct Assay more info	PubMed
involved_in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of tube diameter, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of tube length, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of tube size, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in septate junction assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sodium ion export across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in septate junction	IDA Inferred from Direct Assay more info	PubMed
part_of sodium:potassium-exchanging ATPase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of sodium:potassium-exchanging ATPase complex	IDA Inferred from Direct Assay more info	PubMed
part_of sodium:potassium-exchanging ATPase complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nervana 2

Names: CG9261-PA; CG9261-PC; CG9261-PD; CG9261-PE; CG9261-PF; CG9261-PG; Na+/K+ ATPase; Na,K-ATPase beta-subunit; Na[+]/K[+] ATPase; ectatic; nervana; nervana2; nirvana; nirvana2; nrv2-PA; nrv2-PC; nrv2-PD; nrv2-PE; nrv2-PF; nrv2-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

6789770..6798862 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057820.4 → NP_477168.1 nervana 2, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477168.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24047, Q24048, Q9VM84, Q9VM85

UniProtKB/TrEMBL

A4V0B5

Related

FBpp0079009

Conserved Domains (1) summary

pfam00287
Location:24 → 317

Na_K-ATPase; Sodium / potassium ATPase beta chain
NM_001273235.1 → NP_001260164.1 nervana 2, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260164.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24047, Q24048, Q9VM84, Q9VM85

UniProtKB/TrEMBL

A4V0B5

Conserved Domains (1) summary

pfam00287
Location:24 → 317

Na_K-ATPase; Sodium / potassium ATPase beta chain
NM_001014475.2 → NP_001014475.1 nervana 2, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014475.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24047, Q24048, Q9VM84, Q9VM85

UniProtKB/TrEMBL

A4V0B5

Conserved Domains (1) summary

pfam00287
Location:24 → 317

Na_K-ATPase; Sodium / potassium ATPase beta chain
NM_001014476.2 → NP_001014476.1 nervana 2, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014476.1

Status: REVIEWED

UniProtKB/TrEMBL

Q1RL12

Conserved Domains (1) summary

pfam00287
Location:28 → 316

Na_K-ATPase; Sodium / potassium ATPase beta chain
NM_057821.4 → NP_477169.1 nervana 2, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477169.1

Status: REVIEWED

UniProtKB/TrEMBL

Q1RL12

Related

FBpp0079010

Conserved Domains (1) summary

pfam00287
Location:28 → 316

Na_K-ATPase; Sodium / potassium ATPase beta chain
NM_164711.2 → NP_723216.1 nervana 2, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723216.1

Status: REVIEWED

UniProtKB/TrEMBL

Q1RL12

Related

FBpp0079011

Conserved Domains (1) summary

pfam00287
Location:28 → 316

Na_K-ATPase; Sodium / potassium ATPase beta chain