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    COX7C Cytochrome c oxidase subunit 7C [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 50246, updated on 9-Dec-2024

    Summary

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    Official Symbol
    COX7Cprovided by FlyBase
    Official Full Name
    Cytochrome c oxidase subunit 7Cprovided by FlyBase
    Primary source
    FLYBASE:FBgn0040773
    Locus tag
    Dmel_CG2249
    See related
    AllianceGenome:FB:FBgn0040773
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:fe3A1; BcDNA:LD14731; CG2249; CoAVIIc; CoVIIc; COX-7C; COXO; Dmel\CG2249; VIIc
    Summary
    Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Located in mitochondrion. Is expressed in adult head. Orthologous to human COX7C (cytochrome c oxidase subunit 7C). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See COX7C in Genome Data Viewer
    Location:
    46D7-46D9; 2-61 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10048353..10050066)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5935858..5937571)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene oysgedart Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44295 Neighboring gene antisense RNA:CR44297 Neighboring gene Cytochrome c oxidase subunit 7C-like Neighboring gene seele Neighboring gene magu

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cytochrome c oxidase loses catalytic activity and structural integrity during the aging process in Drosophila melanogaster. Ren JC, et al. Biochem Biophys Res Commun, 2010 Oct 8. PMID 20833144, Free PMC Article
    2. Genetic Reduction of Mitochondria Complex I Subunits is Protective against Cisplatin-Induced Neurotoxicity in Drosophila. Groen CM, et al. J Neurosci, 2022 Feb 2. PMID 34893548, Free PMC Article
    3. Genetic, functional and evolutionary characterization of scox, the Drosophila melanogaster ortholog of the human SCO1 gene. Porcelli D, et al. Mitochondrion, 2010 Aug. PMID 20388558
    4. CG7630 is the Drosophila melanogaster homolog of the cytochrome c oxidase subunit COX7B. Brischigliaro M, et al. EMBO Rep, 2022 Aug 3. PMID 35699132, Free PMC Article
    5. Mitochondria regulate intestinal stem cell proliferation and epithelial homeostasis through FOXO. Zhang F, et al. Mol Biol Cell, 2020 Jul 1. PMID 32374658, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, cytochrome c to oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial electron transport, cytochrome c to oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IC
    Inferred by Curator
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex IV IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex IV ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome c oxidase subunit 7C
    Names
    CG2249-PA
    CG2249-PB
    CG2249-PC
    CG2249-PD
    COX7C-PA
    COX7C-PB
    COX7C-PC
    COX7C-PD
    anon-fast-evolving-3A1
    cytochrome c oxidase VIIc
    cytochrome c oxidase polypeptide VIIc
    cytochrome c oxidase subunit VIIc
    subunit VIIc

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      10048353..10050066
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299339.1 → NP_001286268.1  cytochrome c oxidase subunit 7C, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286268.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JW00
      Conserved Domains (1) summary
      cd00929
      Location:20 → 65
      Cyt_c_Oxidase_VIIc; Cytochrome c oxidase subunit VIIc. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

    2. NM_001299340.1 → NP_001286269.1  cytochrome c oxidase subunit 7C, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286269.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JW00
      Conserved Domains (1) summary
      cd00929
      Location:20 → 65
      Cyt_c_Oxidase_VIIc; Cytochrome c oxidase subunit VIIc. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

    3. NM_144140.3 → NP_652397.1  cytochrome c oxidase subunit 7C, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652397.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JW00
      Related
      FBpp0087484
      Conserved Domains (1) summary
      cd00929
      Location:20 → 65
      Cyt_c_Oxidase_VIIc; Cytochrome c oxidase subunit VIIc. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

    4. NM_176118.3 → NP_788298.1  cytochrome c oxidase subunit 7C, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788298.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JW00
      Related
      FBpp0087485
      Conserved Domains (1) summary
      cd00929
      Location:20 → 65
      Cyt_c_Oxidase_VIIc; Cytochrome c oxidase subunit VIIc. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JW00 Q7JW00

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