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    IPIP Inositol phosphatase interacting protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33849, updated on 9-Dec-2024

    Summary

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    Official Symbol
    IPIPprovided by FlyBase
    Official Full Name
    Inositol phosphatase interacting proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031768
    Locus tag
    Dmel_CG12393
    See related
    AllianceGenome:FB:FBgn0031768
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12393; dIPIP; Dmel\CG12393
    Summary
    Predicted to enable protein homodimerization activity. Involved in endosome organization. Located in endosome. Orthologous to several human genes including PHETA1 (PH domain containing endocytic trafficking adaptor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See IPIP in Genome Data Viewer
    Location:
    26B3-26B3; 2-18 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6048002..6050474)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6048002..6050474)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Phosphoribosylformylglycinamidine synthase Neighboring gene mir-966 stem loop Neighboring gene uncharacterized protein Neighboring gene slowmo Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. IPIP27 Coordinates PtdIns(4,5)P(2) Homeostasis for Successful Cytokinesis. Carim SC, et al. Curr Biol, 2019 Mar 4. PMID 30799246, Free PMC Article
    2. Fractionation profiling: a fast and versatile approach for mapping vesicle proteomes and protein-protein interactions. Borner GH, et al. Mol Biol Cell, 2014 Oct 15. PMID 25165137, Free PMC Article
    3. A Drosophila protein-interaction map centered on cell-cycle regulators. Stanyon CA, et al. Genome Biol, 2004. PMID 15575970, Free PMC Article
    4. Vector and parameters for targeted transgenic RNA interference in Drosophila melanogaster. Ni JQ, et al. Nat Methods, 2008 Jan. PMID 18084299, Free PMC Article
    5. Genes conserved in bilaterians but jointly lost with Myc during nematode evolution are enriched in cell proliferation and cell migration functions. Erives AJ. Dev Genes Evol, 2015 Sep. PMID 26173873, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in endosome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endosome organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in receptor recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in recycling endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    inositol phosphatase interacting protein
    Names
    CG12393-PA
    CG12393-PB
    CG12393-PD
    IPIP-PA
    IPIP-PB
    IPIP-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6048002..6050474
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164678.2 → NP_723149.1  inositol phosphatase interacting protein, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723149.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z022, Q95R37, Q9VMI6
      Related
      FBpp0078814
      Conserved Domains (2) summary
      cd13288
      Location:11 → 127
      PH_Ses; Sesquipedalian family Pleckstrin homology (PH) domain
      pfam00169
      Location:19 → 105
      PH; PH domain

    2. NM_135140.3 → NP_608984.2  inositol phosphatase interacting protein, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608984.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z022, Q95R37, Q9VMI6
      Related
      FBpp0078815
      Conserved Domains (2) summary
      cd13288
      Location:11 → 127
      PH_Ses; Sesquipedalian family Pleckstrin homology (PH) domain
      pfam00169
      Location:19 → 105
      PH; PH domain

    3. NM_001144323.2 → NP_001137795.2  inositol phosphatase interacting protein, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137795.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z022, Q95R37, Q9VMI6
      Conserved Domains (2) summary
      cd13288
      Location:11 → 127
      PH_Ses; Sesquipedalian family Pleckstrin homology (PH) domain
      pfam00169
      Location:19 → 105
      PH; PH domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95R37 Q95R37
    Q9VMI6 Q9VMI6

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