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    Tom Twin of m4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39619, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tomprovided by FlyBase
    Official Full Name
    Twin of m4provided by FlyBase
    Primary source
    FLYBASE:FBgn0026320
    Locus tag
    Dmel_CG5185
    See related
    AllianceGenome:FB:FBgn0026320
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:fe1F6; barbu; Bbu; bbu/tom; CG5185; DmelCG5185; Dmel\CG5185; tom
    Summary
    Enables ubiquitin protein ligase binding activity. Involved in cell fate specification; negative regulation of Notch signaling pathway; and sensory organ precursor cell fate determination. Located in cytoplasm. Is expressed in several structures, including ectoderm anlage; epithelium; germ layer; imaginal disc; and organism subdivision. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tom in Genome Data Viewer
    Location:
    71A3-71A3; 3-42 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (14969344..14970306)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (14962444..14963406)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Brother of Bearded A Neighboring gene long non-coding RNA:CR45978 Neighboring gene Bearded Neighboring gene ocho

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural and functional characterization of the NHR1 domain of the Drosophila neuralized E3 ligase in the notch signaling pathway. He F, et al. J Mol Biol, 2009 Oct 23. PMID 19683535
    2. Expression of E93 provides an instructive cue to control dynamic enhancer activity and chromatin accessibility during development. Nystrom SL, et al. Development, 2020 Mar 16. PMID 32094114, Free PMC Article
    3. Dynamic Notch signalling regulates neural stem cell state progression in the Drosophila optic lobe. Contreras EG, et al. Neural Dev, 2018 Nov 22. PMID 30466475, Free PMC Article
    4. Lateral inhibition: Two modes of non-autonomous negative autoregulation by neuralized. Miller SW, et al. PLoS Genet, 2018 Jul. PMID 30028887, Free PMC Article
    5. Spatial regulation of contractility by Neuralized and Bearded during furrow invagination in Drosophila. Perez-Mockus G, et al. Nat Commun, 2017 Nov 17. PMID 29150614, Free PMC Article

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Snail represses Tom expression in the mesoderm and thereby activates Delta trafficking.
      Title: Dorsal-ventral pattern of Delta trafficking is established by a Snail-Tom-Neuralized pathway.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of Notch signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of Notch signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory organ development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sensory organ precursor cell fate determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    twin of m4
    Names
    CG5185-PA
    Tom-PA
    anon-fast-evolving-1F6
    barbu

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      14969344..14970306
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079349.3 → NP_524073.2  twin of m4 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524073.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U4W9, Q9V3S6
      Related
      FBpp0075373
      Conserved Domains (1) summary
      pfam15952
      Location:1 → 158
      ESM4; Enhancer of split M4 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9U4W9 Q9U4W9
    Q9V3S6 Q9V3S6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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