Nach nach [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Nachprovided by FlyBase
Official Full Name: nachprovided by FlyBase
Primary source: FLYBASE:FBgn0024319
Locus tag: Dmel_CG8178
See related: AllianceGenome:FB:FBgn0024319
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG8178; Dmel\CG8178; ppk4; PPK4
Summary: Enables sodium ion transmembrane transporter activity. Involved in several processes, including intestinal stem cell homeostasis; intracellular water homeostasis; and liquid clearance, open tracheal system. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in Kolbchen; abdominal tracheal metamere; tracheal section; tracheal system; and tracheal tip cell. Orthologous to several human genes including ASIC1 (acid sensing ion channel subunit 1); ASIC2 (acid sensing ion channel subunit 2); and ASIC3 (acid sensing ion channel subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (16653205..16655046, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (12540710..12542551, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ligand-gated sodium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium channel activity	IEA Inferred from Electronic Annotation more info
enables sodium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables sodium channel activity	NAS Non-traceable Author Statement more info	PubMed
enables sodium ion transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in intestinal stem cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular water homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in liquid clearance, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

Names: CG8178-PA; CG8178-PD; CG8178-PE; Nach-PA; Nach-PD; Nach-PE; pickpocket 4

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The following sections contain reference sequences that belong to a specific genome build. Explain