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    CG17841 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31965, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG17841provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028480
    Locus tag
    Dmel_CG17841
    See related
    AllianceGenome:FB:FBgn0028480
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Liang-2.12; BcDNA:GH12326; clone 2.12; Dmel\CG17841
    Summary
    Predicted to be involved in lipid homeostasis. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including adult head; embryonic/larval oenocyte; gastric caecum; and gut section. Used to study chromosome 16p11.2 deletion syndrome, 593-kb. Human ortholog(s) of this gene implicated in cone-rod dystrophy 22. Orthologous to human TLCD3A (TLC domain containing 3A) and TLCD3B (TLC domain containing 3B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG17841 in Genome Data Viewer
    Location:
    9B12-9B14; 1-31 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (10368052..10384183)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (10262085..10277613)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene lethal (1) G0289 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Partner of Sld Five 3 Neighboring gene flapwing Neighboring gene uncharacterized protein Neighboring gene RabX2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dissecting the complexity of CNV pathogenicity: insights from Drosophila and zebrafish models. Yusuff T, et al. Curr Opin Genet Dev, 2021 Jun. PMID 33812298, Free PMC Article
    2. Genetic modifiers of degeneration in the cathepsin D deficient Drosophila model for neuronal ceroid lipofuscinosis. Kuronen M, et al. Neurobiol Dis, 2009 Dec. PMID 19761846
    3. Pervasive genetic interactions modulate neurodevelopmental defects of the autism-associated 16p11.2 deletion in Drosophila melanogaster. Iyer J, et al. Nat Commun, 2018 Jun 29. PMID 29959322, Free PMC Article
    4. Quantitative and molecular genetic analyses of mutations increasing Drosophila life span. Magwire MM, et al. PLoS Genet, 2010 Jul 29. PMID 20686706, Free PMC Article
    5. An expanded toolkit for gene tagging based on MiMIC and scarless CRISPR tagging in Drosophila. Li-Kroeger D, et al. Elife, 2018 Aug 9. PMID 30091705, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in lipid homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG17841-PA
    CG17841-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      10368052..10384183
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132394.4 → NP_572622.1  uncharacterized protein Dmel_CG17841, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572622.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3S7
      Related
      FBpp0071379
      Conserved Domains (1) summary
      smart00724
      Location:127 → 397
      TLC; TRAM, LAG1 and CLN8 homology domains

    2. NM_001369989.1 → NP_001356938.1  uncharacterized protein Dmel_CG17841, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3S7
      Conserved Domains (1) summary
      smart00724
      Location:127 → 397
      TLC; TRAM, LAG1 and CLN8 homology domains
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V3S7 Q9V3S7

    Gene LinkOut

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