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    alpha4GT2 alpha1,4-galactosyltransferase 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43124, updated on 9-Dec-2024

    Summary

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    Official Symbol
    alpha4GT2provided by FlyBase
    Official Full Name
    alpha1,4-galactosyltransferase 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0039378
    Locus tag
    Dmel_CG5878
    See related
    AllianceGenome:FB:FBgn0039378
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5878; Dmel\CG5878
    Summary
    Enables alpha-1,4-N-acetylgalactosaminyltransferase activity. Involved in glycosphingolipid biosynthetic process. Predicted to be located in membrane. Orthologous to human A4GALT (alpha 1,4-galactosyltransferase (P1PK blood group)) and A4GNT (alpha-1,4-N-acetylglucosaminyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See alpha4GT2 in Genome Data Viewer
    Location:
    96F3-96F3; 3-89 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25832230..25842878)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21657952..21668600)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Male-specific RNA 57Db Neighboring gene Male-specific RNA 57Da Neighboring gene long non-coding RNA:CR45653 Neighboring gene long non-coding RNA:CR45654

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila melanogaster homologue of the human histo-blood group Pk gene encodes a glycolipid-modifying alpha1,4-N-acetylgalactosaminyltransferase. Mucha J, et al. Biochem J, 2004 Aug 15. PMID 15130086, Free PMC Article
    2. Glycosphingolipids with extended sugar chain have specialized functions in development and behavior of Drosophila. Chen YW, et al. Dev Biol, 2007 Jun 15. PMID 17498683
    3. Notch ligand activity is modulated by glycosphingolipid membrane composition in Drosophila melanogaster. Hamel S, et al. J Cell Biol, 2010 Feb 22. PMID 20176925, Free PMC Article
    4. Roles of sphingolipids in Drosophila development and disease. Kraut R. J Neurochem, 2011 Mar. PMID 21214556
    5. Genome-wide analysis of retrogene polymorphisms in Drosophila melanogaster. Schrider DR, et al. Genome Res, 2011 Dec. PMID 22135405, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 25832746-25841869 mobile_element_type = transposon:roo{}alpha4GT2[1]

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alpha-1,4-N-acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-1,4-N-acetylgalactosaminyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glycosphingolipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycosphingolipid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    alpha1,4-galactosyltransferase 2
    Names
    CG5878-PB
    alpha4GT2-PB
    NP_651434.3
    • unusual splice

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25832230..25842878
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143177.4 → NP_651434.3  alpha1,4-galactosyltransferase 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651434.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VBL5
      Conserved Domains (2) summary
      pfam04572
      Location:265 → 391
      Gb3_synth; Alpha 1,4-glycosyltransferase conserved region
      cl19952
      Location:129 → 241
      Gly_transf_sug; Glycosyltransferase sugar-binding region containing DXD motif
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VBL5 Q9VBL5

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