dl dorsal [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: dlprovided by FlyBase
Official Full Name: dorsalprovided by FlyBase
Primary source: FLYBASE:FBgn0260632
Locus tag: Dmel_CG6667
See related: AllianceGenome:FB:FBgn0260632
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-EST:GressD7; CG6667; dL; Dl; DL; Dmel\CG6667; Dor; Dorsal; fs(2)k10816; GSd447; mat(2)dorsal; NF-kappaB; NF-KB; NFkappaB; p65
Summary: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and high mobility group box 1 binding activity. Involved in several processes, including Toll signaling pathway; positive regulation of hemocyte proliferation; and positive regulation of macromolecule biosynthetic process. Located in several cellular components, including cytosol; neuromuscular junction; and subsynaptic reticulum. Is expressed in several structures, including adult head; embryonic/larval hypodermal muscle cell; epithelium; germline cell; and neuromuscular junction. Human ortholog(s) of this gene implicated in ductal carcinoma in situ; lung non-small cell carcinoma; lymphoma; primary immunodeficiency disease; and renal cell carcinoma. Orthologous to several human genes including RELA (RELA proto-oncogene, NF-kB subunit). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 36C8-36C9; 2-53 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (17436830..17450364, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (17436830..17450364, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Generation and timing of graded responses to morphogen gradients.
Title: Generation and timing of graded responses to morphogen gradients.
Drosophila ELYS regulates Dorsal dynamics during development.
Title: Drosophila ELYS regulates Dorsal dynamics during development.
Notch-responsive enhancers are activated synchronously in Drosophila embryos; Priming by Twist and Dorsal promotes fast and sustained response to Notch
Title: Enhancer Priming Enables Fast and Sustained Transcriptional Responses to Notch Signaling.
These results suggest that synergistic interactions between Dl and Zld and between DI and Bcd are required for broad sog expression.
Title: The short gastrulation shadow enhancer employs dual modes of transcriptional synergy.
Dorsal, a Drosophila homolog of NF-kappaB, patterns the dorsal-ventral axis in the blastoderm embryo. During this stage, Dorsal is sequestered outside the nucleus by the IkappaB homolog Cactus. Dorsal accumulates on the ventral side of the syncytial blastoderm. We use modeling and experimental studies to show that this accumulation is caused by facilitated diffusion, or shuttling, of the Dorsal/Cactus complex.
Title: A facilitated diffusion mechanism establishes the Drosophila Dorsal gradient.
ere, we describe an extensive, quantitative perturbation analysis targeting the dorsal-ventral patterning gene regulatory network (GRN) controlled by Drosophila NF-kappaB homolog Dorsal.
Title: Quantitative perturbation-based analysis of gene expression predicts enhancer activity in early Drosophila embryo.
It has been shown that Dorsal repressed Ush expression levels to promote hemocytes differentiation, whereas Cactus maintained Ush levels to block differentiation.
Title: The Friend of GATA Transcriptional Co-Regulator, U-Shaped, Is a Downstream Antagonist of Dorsal-Driven Prohemocyte Differentiation in Drosophila.
There is a clear positive correlation between the number of Zld binding sites and the spatial domain of enhancer activity. Zld facilitates binding of Dl to regulatory DNA, and this is associated with increased chromatin accessibility.
Title: Zelda potentiates morphogen activity by increasing chromatin accessibility.
The Toll-dorsal pathway is required for resistance to viral oral infection in Drosophila.
Title: The Toll-dorsal pathway is required for resistance to viral oral infection in Drosophila.
demonstrated that the core promoter composition is an important determinant of transcriptional activity of Dorsal target genes
Title: Core promoter functions in the regulation of gene expression of Drosophila dorsal target genes.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
contributes_to DNA-binding transcription factor activity, RNA polymerase II-specific	IGI Inferred from Genetic Interaction more info	PubMed
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables high mobility group box 1 binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in Toll signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in Toll signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in Toll signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in dorsal/ventral axis specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dorsal/ventral pattern formation	IDA Inferred from Direct Assay more info	PubMed
involved_in dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immune response	IEP Inferred from Expression Pattern more info	PubMed
involved_in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in melanization defense response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in non-canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in peripheral nervous system neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of antimicrobial peptide production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of hemocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of hemocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of hemocyte proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in response to cytokine	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in subsynaptic reticulum	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: dorsal

Names: CG6667-PA; CG6667-PB; CG6667-PC; CG6667-PD; CG6667-PE; CG6667-PF; DORSAL; Dorsal/NF-kappaB; NFkappabeta; dl-PA; dl-PB; dl-PC; dl-PD; dl-PE; dl-PF; embryonic polarity protein dorsal

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

17436830..17450364 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_165217.3 → NP_724052.1 dorsal, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724052.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JHK3

Related

FBpp0080558

Conserved Domains (2) summary

cd07887
Location:47 → 220

RHD-n_Dorsal_Dif; N-terminal sub-domain of the Rel homology domain (RHD) of the arthropod protein Dorsal

cd01177
Location:225 → 326

IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
NM_165218.3 → NP_724053.1 dorsal, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724053.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JHK3

Related

FBpp0080559

Conserved Domains (2) summary

cd07887
Location:47 → 220

RHD-n_Dorsal_Dif; N-terminal sub-domain of the Rel homology domain (RHD) of the arthropod protein Dorsal

cd01177
Location:225 → 326

IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
NM_001169530.1 → NP_001163001.1 dorsal, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163001.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JHK3

Conserved Domains (2) summary

cd07887
Location:47 → 220

RHD-n_Dorsal_Dif; N-terminal sub-domain of the Rel homology domain (RHD) of the arthropod protein Dorsal

cd01177
Location:225 → 326

IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
NM_001169529.1 → NP_001163000.1 dorsal, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163000.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JHK3

Conserved Domains (2) summary

cd07887
Location:47 → 220

RHD-n_Dorsal_Dif; N-terminal sub-domain of the Rel homology domain (RHD) of the arthropod protein Dorsal

cd01177
Location:225 → 326

IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
NM_165219.2 → NP_724054.1 dorsal, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724054.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O77088, P15330, Q0E8P9, Q6AWP3, Q9VJD9, Q9VJE0

UniProtKB/TrEMBL

C7LA93

Related

FBpp0080560

Conserved Domains (2) summary

cd07887
Location:47 → 220

RHD-n_Dorsal_Dif; N-terminal sub-domain of the Rel homology domain (RHD) of the arthropod protein Dorsal

cd01177
Location:225 → 326

IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
NM_001299085.1 → NP_001286014.1 dorsal, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286014.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O77088, P15330, Q0E8P9, Q6AWP3, Q9VJD9, Q9VJE0

UniProtKB/TrEMBL

C7LA93

Conserved Domains (2) summary

cd07887
Location:47 → 220

RHD-n_Dorsal_Dif; N-terminal sub-domain of the Rel homology domain (RHD) of the arthropod protein Dorsal

cd01177
Location:225 → 326

IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...