wek weckle [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: wekprovided by FlyBase
Official Full Name: weckleprovided by FlyBase
Primary source: FLYBASE:FBgn0001990
Locus tag: Dmel_CG4148
See related: AllianceGenome:FB:FBgn0001990
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BG:DS09217.5; CG4148; Dmel\CG4148; l(2)35Ea; l(2)br47; l35Ea; WECKLE; Wek
Summary: Enables protein homodimerization activity and signaling adaptor activity. Involved in Toll signaling pathway and dorsal/ventral axis specification. Located in cytoplasmic side of plasma membrane and nucleus. Is expressed in organism. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (15766133..15768349, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (15766133..15768349, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables signaling adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Toll signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in activation of innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal/ventral axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maternal specification of dorsal/ventral axis, oocyte, germ-line encoded	HMP more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

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The following sections contain reference sequences that belong to a specific genome build. Explain