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    ZNF615 zinc finger protein 615 [ Homo sapiens (human) ]

    Gene ID: 284370, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF615provided by HGNC
    Official Full Name
    zinc finger protein 615provided by HGNC
    Primary source
    HGNC:HGNC:24740
    See related
    Ensembl:ENSG00000197619 AllianceGenome:HGNC:24740
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in prostate (RPKM 9.4), thyroid (RPKM 3.7) and 24 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF615 in Genome Data Viewer
    Location:
    19q13.41
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (51991332..52008211, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (55078529..55095409, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (52494585..52511464, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 613 Neighboring gene ZNF350 antisense RNA 1 Neighboring gene zinc finger protein 350 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:52489558-52490433 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15032 Neighboring gene uncharacterized LOC124904755 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15033 Neighboring gene zinc finger protein 614 Neighboring gene uncharacterized LOC112268244 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:52530119-52530889 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15034

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells. Chang YJ, et al. Int J Mol Sci, 2023 Jun 6. PMID 37372979, Free PMC Article
    2. ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold. Yang W, et al. Theranostics, 2022. PMID 36168627, Free PMC Article
    3. Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling. Kouranti I, et al. Int J Mol Sci, 2022 May 5. PMID 35563538, Free PMC Article
    4. VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Yue Y, et al. Cell Discov, 2018. PMID 29507755, Free PMC Article
    5. A proximity-dependent biotinylation map of a human cell. Go CD, et al. Nature, 2021 Jul. PMID 34079125

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ33710, FLJ39372, DKFZp686O1554

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 615

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199324.2 → NP_001186253.1  zinc finger protein 615 isoform 1

      See identical proteins and their annotated locations for NP_001186253.1

      Status: VALIDATED

      Source sequence(s)
      AC011460, BC053884, BC112961, BX647556, DA095942
      Consensus CDS
      CCDS59418.1
      UniProtKB/Swiss-Prot
      Q8N8J6
      Related
      ENSP00000471041.1, ENST00000598071.6
      Conserved Domains (5) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:325 → 729
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:413 → 433
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:8 → 47
      KRAB; KRAB box
      pfam13465
      Location:426 → 449
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001321317.2 → NP_001308246.1  zinc finger protein 615 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC011460, AK294977, BC053884, BX647556
      Consensus CDS
      CCDS82387.1
      UniProtKB/TrEMBL
      H9KV89
      Related
      ENSP00000375672.3, ENST00000391795.7
      Conserved Domains (5) summary
      smart00349
      Location:13 → 73
      KRAB; krueppel associated box
      COG5048
      Location:319 → 723
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:407 → 427
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:13 → 52
      KRAB; KRAB box
      pfam13465
      Location:420 → 443
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001321318.2 → NP_001308247.1  zinc finger protein 615 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC011460, AC011468, AK128361, BX647556
      UniProtKB/Swiss-Prot
      Q8N8J6
      Conserved Domains (5) summary
      smart00349
      Location:4 → 64
      KRAB; krueppel associated box
      COG5048
      Location:321 → 725
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:409 → 429
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4 → 43
      KRAB; KRAB box
      pfam13465
      Location:422 → 445
      zf-H2C2_2; Zinc-finger double domain

    4. NM_001321319.2 → NP_001308248.1  zinc finger protein 615 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC011460, AC011468, BC112961, BX647556
      Consensus CDS
      CCDS59418.1
      UniProtKB/Swiss-Prot
      Q8N8J6
      Related
      ENSP00000471549.1, ENST00000594083.5
      Conserved Domains (5) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:325 → 729
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:413 → 433
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:8 → 47
      KRAB; KRAB box
      pfam13465
      Location:426 → 449
      zf-H2C2_2; Zinc-finger double domain

    5. NM_001321320.2 → NP_001308249.1  zinc finger protein 615 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC011460, AC011468, BX647556, DA119086, DB235427, DB290987
      Consensus CDS
      CCDS12846.1
      UniProtKB/Swiss-Prot
      B7ZKW9, Q2M2Y6, Q5CZB0, Q6ZMT7, Q6ZRB3, Q8N8J6
      Conserved Domains (5) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:314 → 718
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:402 → 422
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:8 → 47
      KRAB; KRAB box
      pfam13465
      Location:415 → 438
      zf-H2C2_2; Zinc-finger double domain

    6. NM_001321321.2 → NP_001308250.1  zinc finger protein 615 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC011460, AC011468, BX647556, DA322276, DA802380
      Consensus CDS
      CCDS59418.1
      UniProtKB/Swiss-Prot
      Q8N8J6
      Related
      ENSP00000483676.1, ENST00000618487.4
      Conserved Domains (5) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:325 → 729
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:413 → 433
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:8 → 47
      KRAB; KRAB box
      pfam13465
      Location:426 → 449
      zf-H2C2_2; Zinc-finger double domain

    7. NM_001321322.2 → NP_001308251.1  zinc finger protein 615 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC011460, BX647556, DA322276
      Conserved Domains (5) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:321 → 725
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:409 → 429
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:8 → 47
      KRAB; KRAB box
      pfam13465
      Location:422 → 445
      zf-H2C2_2; Zinc-finger double domain

    8. NM_001321323.2 → NP_001308252.1  zinc finger protein 615 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC011460, BX647556, DA240372
      Conserved Domains (5) summary
      smart00349
      Location:13 → 73
      KRAB; krueppel associated box
      COG5048
      Location:330 → 734
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:418 → 438
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:13 → 52
      KRAB; KRAB box
      pfam13465
      Location:431 → 454
      zf-H2C2_2; Zinc-finger double domain

    9. NM_198480.4 → NP_940882.3  zinc finger protein 615 isoform 2

      See identical proteins and their annotated locations for NP_940882.3

      Status: VALIDATED

      Source sequence(s)
      AC011460, AK094071, BC105100, BX647556, DA236166, DA244381
      Consensus CDS
      CCDS12846.1
      UniProtKB/Swiss-Prot
      B7ZKW9, Q2M2Y6, Q5CZB0, Q6ZMT7, Q6ZRB3, Q8N8J6
      Related
      ENSP00000365906.4, ENST00000376716.9
      Conserved Domains (5) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:314 → 718
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:402 → 422
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:8 → 47
      KRAB; KRAB box
      pfam13465
      Location:415 → 438
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      51991332..52008211 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438647.1 → XP_047294603.1  zinc finger protein 615 isoform X1

    2. XM_017026648.3 → XP_016882137.1  zinc finger protein 615 isoform X2

      UniProtKB/Swiss-Prot
      B7ZKW9, Q2M2Y6, Q5CZB0, Q6ZMT7, Q6ZRB3, Q8N8J6
      Conserved Domains (5) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:314 → 718
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:402 → 422
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:8 → 47
      KRAB; KRAB box
      pfam13465
      Location:415 → 438
      zf-H2C2_2; Zinc-finger double domain

    3. XM_047438644.1 → XP_047294600.1  zinc finger protein 615 isoform X1

    4. XM_047438645.1 → XP_047294601.1  zinc finger protein 615 isoform X1

    5. XM_047438646.1 → XP_047294602.1  zinc finger protein 615 isoform X1

    6. XM_047438648.1 → XP_047294604.1  zinc finger protein 615 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      55078529..55095409 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320646.1 → XP_054176621.1  zinc finger protein 615 isoform X1

    2. XM_054320647.1 → XP_054176622.1  zinc finger protein 615 isoform X2

      UniProtKB/Swiss-Prot
      B7ZKW9, Q2M2Y6, Q5CZB0, Q6ZMT7, Q6ZRB3, Q8N8J6

    3. XM_054320643.1 → XP_054176618.1  zinc finger protein 615 isoform X1

    4. XM_054320644.1 → XP_054176619.1  zinc finger protein 615 isoform X1

    5. XM_054320645.1 → XP_054176620.1  zinc finger protein 615 isoform X1

    6. XM_054320648.1 → XP_054176623.1  zinc finger protein 615 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N8J6.2 GenPept UniProtKB/Swiss-Prot:Q8N8J6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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