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    ZNF577 zinc finger protein 577 [ Homo sapiens (human) ]

    Gene ID: 84765, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF577provided by HGNC
    Official Full Name
    zinc finger protein 577provided by HGNC
    Primary source
    HGNC:HGNC:28673
    See related
    Ensembl:ENSG00000161551 AllianceGenome:HGNC:28673
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in skin (RPKM 6.4), ovary (RPKM 5.9) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF577 in Genome Data Viewer
    Location:
    19q13.41
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (51804442..51887951, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (54889344..54975146, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (52307695..52391204, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 3543 Neighboring gene formyl peptide receptor 2 Neighboring gene uncharacterized LOC105372448 Neighboring gene formyl peptide receptor 3 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:52350575-52351774 Neighboring gene zinc finger protein 84 pseudogene Neighboring gene vomeronasal 1 receptor 98 pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr19:52382957-52383477 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:52390477-52391328 Neighboring gene ZNF649 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:52404806-52405052 Neighboring gene zinc finger protein 649 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:52406403-52406948 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:52408039-52408583 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:52408912-52409536 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:52410420-52411095 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:52411096-52411770 Neighboring gene zinc finger protein 41 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. ZNF577 Methylation Levels in Leukocytes From Women With Breast Cancer Is Modulated by Adiposity, Menopausal State, and the Mediterranean Diet. Lorenzo PM, et al. Front Endocrinol (Lausanne), 2020. PMID 32390948, Free PMC Article
    2. Potential novel candidate polymorphisms identified in genome-wide association study for breast cancer susceptibility. Sehrawat B, et al. Hum Genet, 2011 Oct. PMID 21424380, Free PMC Article
    3. The interactome of KRAB zinc finger proteins reveals the evolutionary history of their functional diversification. Helleboid PY, et al. EMBO J, 2019 Sep 16. PMID 31403225, Free PMC Article
    4. Protein interaction discovery using parallel analysis of translated ORFs (PLATO). Zhu J, et al. Nat Biotechnol, 2013 Apr. PMID 23503679, Free PMC Article
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZNF577 Methylation Levels in Leukocytes From Women With Breast Cancer Is Modulated by Adiposity, Menopausal State, and the Mediterranean Diet.
      Title: ZNF577 Methylation Levels in Leukocytes From Women With Breast Cancer Is Modulated by Adiposity, Menopausal State, and the Mediterranean Diet.
    2. Single nucleotide polymorphisms in ZNF577 gene is associated with breast cancer.
      Title: Potential novel candidate polymorphisms identified in genome-wide association study for breast cancer susceptibility.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Potential novel candidate polymorphisms identified in genome-wide association study for breast cancer susceptibility.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC4400, FLJ32291, AC006272.1

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 577

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135590.2 → NP_001129062.1  zinc finger protein 577 isoform b

      See identical proteins and their annotated locations for NP_001129062.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The resulting isoform (b) is shorter than isoform a.
      Source sequence(s)
      AC011460, AC074141, AK289479, AK291812, BC004992, BU949047
      Consensus CDS
      CCDS46160.1
      UniProtKB/TrEMBL
      A0A1W2PQ54
      Related
      ENSP00000389652.2, ENST00000451628.9
      Conserved Domains (3) summary
      smart00349
      Location:25 → 83
      KRAB; krueppel associated box
      COG5048
      Location:135 → 340
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:157 → 177
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001370447.1 → NP_001357376.1  zinc finger protein 577 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC074141, AI004737, AK289479, DA747815
      Consensus CDS
      CCDS12842.2
      UniProtKB/Swiss-Prot
      A8K0B4, A8K6Z7, C9JFB9, Q9BSK1
      UniProtKB/TrEMBL
      A0A1W2PQ54
      Conserved Domains (3) summary
      smart00349
      Location:25 → 83
      KRAB; krueppel associated box
      COG5048
      Location:194 → 399
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:216 → 236
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_001370448.1 → NP_001357377.1  zinc finger protein 577 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC074141, AI004737, AK289479, DA747815, DA874803
      Consensus CDS
      CCDS12842.2
      UniProtKB/Swiss-Prot
      A8K0B4, A8K6Z7, C9JFB9, Q9BSK1
      UniProtKB/TrEMBL
      A0A1W2PQ54
      Conserved Domains (3) summary
      smart00349
      Location:25 → 83
      KRAB; krueppel associated box
      COG5048
      Location:194 → 399
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:216 → 236
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. NM_001370449.1 → NP_001357378.1  zinc finger protein 577 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC074141, AI004737, AK093036, AK289479, AL832871
      Consensus CDS
      CCDS12842.2
      UniProtKB/Swiss-Prot
      A8K0B4, A8K6Z7, C9JFB9, Q9BSK1
      UniProtKB/TrEMBL
      A0A1W2PQ54
      Related
      ENSP00000491936.2, ENST00000638348.2
      Conserved Domains (3) summary
      smart00349
      Location:25 → 83
      KRAB; krueppel associated box
      COG5048
      Location:194 → 399
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:216 → 236
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. NM_001370450.1 → NP_001357379.1  zinc finger protein 577 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC074141, AI004737, AK093036, AK289479, AK291812, AL832871
      Consensus CDS
      CCDS46160.1
      UniProtKB/TrEMBL
      A0A1W2PQ54
      Related
      ENSP00000491349.1, ENST00000639636.2
      Conserved Domains (3) summary
      smart00349
      Location:25 → 83
      KRAB; krueppel associated box
      COG5048
      Location:135 → 340
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:157 → 177
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. NM_001370452.1 → NP_001357381.1  zinc finger protein 577 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC006272, AC011460, AC074141
      UniProtKB/TrEMBL
      A0A1W2PRX5
      Conserved Domains (1) summary
      smart00349
      Location:25 → 83
      KRAB; krueppel associated box

    7. NM_001370455.1 → NP_001357384.1  zinc finger protein 577 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC006272, AC011460, AC074141
      UniProtKB/TrEMBL
      A0A1W2PRX5
      Conserved Domains (1) summary
      smart00349
      Location:25 → 83
      KRAB; krueppel associated box

    8. NM_001370456.1 → NP_001357385.1  zinc finger protein 577 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC006272, AC011460, AC074141
      UniProtKB/TrEMBL
      A0A1W2PRX5
      Conserved Domains (1) summary
      smart00349
      Location:25 → 83
      KRAB; krueppel associated box

    9. NM_001370457.1 → NP_001357386.1  zinc finger protein 577 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC006272, AC011460, AC074141
      UniProtKB/TrEMBL
      A0A1W2PRX5
      Related
      ENSP00000492704.1, ENST00000638827.1
      Conserved Domains (1) summary
      smart00349
      Location:25 → 83
      KRAB; krueppel associated box

    10. NM_032679.3 → NP_116068.2  zinc finger protein 577 isoform a

      See identical proteins and their annotated locations for NP_116068.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC074141, AK289479, BC004992, BU949047
      Consensus CDS
      CCDS12842.2
      UniProtKB/Swiss-Prot
      A8K0B4, A8K6Z7, C9JFB9, Q9BSK1
      UniProtKB/TrEMBL
      A0A1W2PQ54
      Related
      ENSP00000301399.5, ENST00000301399.12
      Conserved Domains (3) summary
      smart00349
      Location:25 → 83
      KRAB; krueppel associated box
      COG5048
      Location:194 → 399
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:216 → 236
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RNA

    1. NR_163433.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC005946, AC006272, AC011460, AC074141

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      51804442..51887951 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047439551.1 → XP_047295507.1  zinc finger protein 577 isoform X2

      UniProtKB/TrEMBL
      A0A1W2PQ54

    2. XM_047439550.1 → XP_047295506.1  zinc finger protein 577 isoform X1

      UniProtKB/Swiss-Prot
      A8K0B4, A8K6Z7, C9JFB9, Q9BSK1
      UniProtKB/TrEMBL
      A0A1W2PQ54

    RNA

    1. XR_007067021.1 RNA Sequence

    2. XR_007067020.1 RNA Sequence

    3. XR_007067019.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      54889344..54975146 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322405.1 → XP_054178380.1  zinc finger protein 577 isoform X2

      UniProtKB/TrEMBL
      A0A1W2PQ54

    2. XM_054322404.1 → XP_054178379.1  zinc finger protein 577 isoform X1

      UniProtKB/Swiss-Prot
      A8K0B4, A8K6Z7, C9JFB9, Q9BSK1
      UniProtKB/TrEMBL
      A0A1W2PQ54

    RNA

    1. XR_008485211.1 RNA Sequence

    2. XR_008485213.1 RNA Sequence

    3. XR_008485212.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BSK1.3 GenPept UniProtKB/Swiss-Prot:Q9BSK1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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