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    PSG5 pregnancy specific beta-1-glycoprotein 5 [ Homo sapiens (human) ]

    Gene ID: 5673, updated on 10-Dec-2024

    Summary

    Official Symbol
    PSG5provided by HGNC
    Official Full Name
    pregnancy specific beta-1-glycoprotein 5provided by HGNC
    Primary source
    HGNC:HGNC:9522
    See related
    Ensembl:ENSG00000204941 MIM:176394; AllianceGenome:HGNC:9522
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PSG; FL-NCA-3
    Summary
    The human pregnancy-specific glycoproteins (PSGs) are a group of molecules that are mainly produced by the placental syncytiotrophoblasts during pregnancy. PSGs comprise a subgroup of the carcinoembryonic antigen (CEA) family, which belongs to the immunoglobulin superfamily. For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009]
    Expression
    Restricted expression toward placenta (RPKM 117.8) See more
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    Genomic context

    See PSG5 in Genome Data Viewer
    Location:
    19q13.31
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (43167743..43186536, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (45988311..46007149, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (43671895..43690688, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene pregnancy specific beta-1-glycoprotein 2 Neighboring gene CEA cell adhesion molecule pseudogene 9 Neighboring gene PSG11, PSG2 and PSG5 antisense RNA 1 Neighboring gene pregnancy specific beta-1-glycoprotein 9 pseudogene Neighboring gene pregnancy specific beta-1-glycoprotein 4 Neighboring gene uncharacterized LOC284344 Neighboring gene CEA cell adhesion molecule pseudogene 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in female pregnancy TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    pregnancy-specific beta-1-glycoprotein 5
    Names
    PS-beta-G-5
    PSBG-5
    Pregnancy-specific beta-1-glycoprotein-5
    fetal liver non-specific cross-reactive antigen 3
    pregnancy-specific beta 1 glycoprotein
    pregnancy-specific glycoprotein 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130014.2NP_001123486.1  pregnancy-specific beta-1-glycoprotein 5 precursor

      See identical proteins and their annotated locations for NP_001123486.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks a segment in the 3' exon, as compared to variant 1.
      Source sequence(s)
      AA151017, BC012607, BG622527, DA835167, M25384, M73713
      Consensus CDS
      CCDS12617.1
      UniProtKB/Swiss-Prot
      Q15238, Q15239, Q96QJ1, Q9UQ75
      UniProtKB/TrEMBL
      E7EQY3
      Related
      ENSP00000386008.1, ENST00000407356.5
      Conserved Domains (4) summary
      cd05774
      Location:36138
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:246320
      IG_like; Immunoglobulin like
      pfam13895
      Location:242320
      Ig_2; Immunoglobulin domain
      cl11960
      Location:148236
      Ig; Immunoglobulin domain
    2. NM_002781.4NP_002772.3  pregnancy-specific beta-1-glycoprotein 5 precursor

      See identical proteins and their annotated locations for NP_002772.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC012607, BG621332, BG622527, DA835167, M25384
      Consensus CDS
      CCDS12617.1
      UniProtKB/Swiss-Prot
      Q15238, Q15239, Q96QJ1, Q9UQ75
      UniProtKB/TrEMBL
      E7EQY3
      Related
      ENSP00000344413.6, ENST00000342951.11
      Conserved Domains (4) summary
      cd05774
      Location:36138
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:246320
      IG_like; Immunoglobulin like
      pfam13895
      Location:242320
      Ig_2; Immunoglobulin domain
      cl11960
      Location:148236
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      43167743..43186536 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017027003.2XP_016882492.1  pregnancy-specific beta-1-glycoprotein 5 isoform X1

      UniProtKB/Swiss-Prot
      Q15238, Q15239, Q96QJ1, Q9UQ75
      UniProtKB/TrEMBL
      E7EQY3
      Conserved Domains (4) summary
      cd05774
      Location:36138
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:246320
      IG_like; Immunoglobulin like
      pfam13895
      Location:242320
      Ig_2; Immunoglobulin domain
      cl11960
      Location:148236
      Ig; Immunoglobulin domain
    2. XM_011527132.4XP_011525434.1  pregnancy-specific beta-1-glycoprotein 5 isoform X2

      Conserved Domains (1) summary
      cd05774
      Location:36138
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      45988311..46007149 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321490.1XP_054177465.1  pregnancy-specific beta-1-glycoprotein 5 isoform X1

      UniProtKB/TrEMBL
      E7EQY3
    2. XM_054321491.1XP_054177466.1  pregnancy-specific beta-1-glycoprotein 5 isoform X2