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    Ttk Ttk protein kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315852, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Ttkprovided by RGD
    Official Full Name
    Ttk protein kinaseprovided by RGD
    Primary source
    RGD:1305558
    See related
    EnsemblRapid:ENSRNOG00000029055 AllianceGenome:RGD:1305558
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mps1
    Summary
    Predicted to enable identical protein binding activity; kinetochore binding activity; and protein kinase activity. Predicted to be involved in negative regulation of metaphase/anaphase transition of cell cycle; protein localization to kinetochore; and repair of mitotic kinetochore microtubule attachment defect. Predicted to act upstream of or within female meiosis chromosome segregation; protein localization to organelle; and protein phosphorylation. Predicted to be located in cytoplasm. Predicted to be active in kinetochore and nucleus. Orthologous to human TTK (TTK protein kinase). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Thymus (RPKM 91.2), Testes (RPKM 91.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ttk in Genome Data Viewer
    Location:
    8q31
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (93632678..93672664)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (84754329..84792653)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (91368065..91405995)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L32 like 4 Neighboring gene ELOVL fatty acid elongase 4 Neighboring gene uncharacterized LOC108351756 Neighboring gene uncharacterized LOC102557516

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Multiple cDNAs encoding the esk kinase predict transmembrane and intracellular enzyme isoforms. Douville EM, et al. Mol Cell Biol, 1992 Jun. PMID 1375325, Free PMC Article
    2. Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress. Foijer F, et al. Proc Natl Acad Sci U S A, 2014 Sep 16. PMID 25197064, Free PMC Article
    3. Mps1 at kinetochores is essential for female mouse meiosis I. Hached K, et al. Development, 2011 Jun. PMID 21558374
    4. Comprehensive Molecular Analyses of a Macrophage-Related Gene Signature With Regard to Prognosis, Immune Features, and Biomarkers for Immunotherapy in Hepatocellular Carcinoma Based on WGCNA and the LASSO Algorithm. Wang T, et al. Front Immunol, 2022. PMID 35693827, Free PMC Article
    5. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinetochore binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine/tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine/tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within female meiosis chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in meiotic spindle assembly checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within meiotic spindle assembly checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic spindle assembly checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein localization to chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein localization to kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein localization to meiotic spindle midzone ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in repair of mitotic kinetochore microtubule attachment defect ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dual specificity protein kinase TTK
    Names
    Monopolar spindle 1
    NP_001101642.1
    NP_001387981.1
    XP_006243522.1
    XP_006243523.1
    XP_006243524.1
    XP_006243525.1
    XP_006243526.1
    XP_006243527.1
    XP_006243528.1
    XP_038937454.1
    XP_038937455.1
    XP_038937456.1
    XP_063121625.1
    XP_063121627.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108172.1 → NP_001101642.1  dual specificity protein kinase TTK isoform 2

      Status: PROVISIONAL

      Source sequence(s)
      CH473954
      UniProtKB/TrEMBL
      A6I1S0, A6I1S3
      Related
      ENSRNOP00000079704.1, ENSRNOT00000114297.2
      Conserved Domains (2) summary
      cd14131
      Location:501 → 769
      PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)
      pfam00069
      Location:503 → 769
      Pkinase; Protein kinase domain

    2. NM_001401052.1 → NP_001387981.1  dual specificity protein kinase TTK isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6I1S3, D4A4S7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      93632678..93672664
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265555.1 → XP_063121625.1  dual specificity protein kinase TTK isoform X4

      UniProtKB/TrEMBL
      A6I1S3, D4A4S7

    2. XM_006243460.5 → XP_006243522.1  dual specificity protein kinase TTK isoform X1

      UniProtKB/TrEMBL
      A6I1S3
      Conserved Domains (2) summary
      cd14131
      Location:530 → 798
      PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)
      pfam00069
      Location:532 → 798
      Pkinase; Protein kinase domain

    3. XM_006243461.5 → XP_006243523.1  dual specificity protein kinase TTK isoform X2

      UniProtKB/TrEMBL
      A0A0G2K2S5, A6I1S3
      Related
      ENSRNOP00000042156.4, ENSRNOT00000051612.4
      Conserved Domains (2) summary
      cd14131
      Location:529 → 797
      PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)
      pfam00069
      Location:531 → 797
      Pkinase; Protein kinase domain

    4. XM_039081527.2 → XP_038937455.1  dual specificity protein kinase TTK isoform X5

      UniProtKB/TrEMBL
      A6I1S3
      Conserved Domains (1) summary
      cd14131
      Location:514 → 782
      PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)

    5. XM_039081528.2 → XP_038937456.1  dual specificity protein kinase TTK isoform X6

      UniProtKB/TrEMBL
      A6I1S3
      Conserved Domains (1) summary
      cd14131
      Location:442 → 710
      PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)

    6. XM_006243463.5 → XP_006243525.1  dual specificity protein kinase TTK isoform X3

      UniProtKB/TrEMBL
      A6I1S3
      Conserved Domains (2) summary
      cd14131
      Location:519 → 787
      PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)
      pfam00069
      Location:521 → 787
      Pkinase; Protein kinase domain

    7. XM_039081526.2 → XP_038937454.1  dual specificity protein kinase TTK isoform X4

      UniProtKB/TrEMBL
      A6I1S3, D4A4S7
      Conserved Domains (1) summary
      cd14131
      Location:518 → 786
      PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)

    8. XM_006243465.5 → XP_006243527.1  dual specificity protein kinase TTK isoform X3

      UniProtKB/TrEMBL
      A6I1S3
      Conserved Domains (2) summary
      cd14131
      Location:519 → 787
      PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)
      pfam00069
      Location:521 → 787
      Pkinase; Protein kinase domain

    9. XM_063265557.1 → XP_063121627.1  dual specificity protein kinase TTK isoform X4

      UniProtKB/TrEMBL
      A6I1S3, D4A4S7

    10. XM_006243462.5 → XP_006243524.1  dual specificity protein kinase TTK isoform X3

      UniProtKB/TrEMBL
      A6I1S3
      Related
      ENSRNOP00000072355.2, ENSRNOT00000083151.3
      Conserved Domains (2) summary
      cd14131
      Location:519 → 787
      PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)
      pfam00069
      Location:521 → 787
      Pkinase; Protein kinase domain

    11. XM_006243464.5 → XP_006243526.1  dual specificity protein kinase TTK isoform X3

      UniProtKB/TrEMBL
      A6I1S3
      Conserved Domains (2) summary
      cd14131
      Location:519 → 787
      PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)
      pfam00069
      Location:521 → 787
      Pkinase; Protein kinase domain

    12. XM_006243466.4 → XP_006243528.1  dual specificity protein kinase TTK isoform X3

      UniProtKB/TrEMBL
      A6I1S3
      Conserved Domains (2) summary
      cd14131
      Location:519 → 787
      PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)
      pfam00069
      Location:521 → 787
      Pkinase; Protein kinase domain
    Nucleotide Protein Strain
    Heading Accession and Version

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