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    Hexim2 HEXIM P-TEFb complex subunit 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303580, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hexim2provided by RGD
    Official Full Name
    HEXIM P-TEFb complex subunit 2provided by RGD
    Primary source
    RGD:1311635
    See related
    EnsemblRapid:ENSRNOG00000021287 AllianceGenome:RGD:1311635
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311635
    Summary
    Predicted to enable 7SK snRNA binding activity; cyclin-dependent protein serine/threonine kinase inhibitor activity; and identical protein binding activity. Predicted to be involved in negative regulation of cyclin-dependent protein serine/threonine kinase activity and negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nuclear speck. Predicted to be active in cytoplasm and nucleoplasm. Orthologous to human HEXIM2 (HEXIM P-TEFb complex subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 66.2), Thymus (RPKM 55.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hexim2 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (88572102..88584856)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (88077870..88084776)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (91212296..91222841)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene acyl-CoA binding domain containing 4 Neighboring gene HEXIM P-TEFb complex subunit 1 Neighboring gene formin-like 1 Neighboring gene EF-hand calcium binding domain 15 Neighboring gene spermatogenesis associated 32

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Glycosylation analysis of IgLON family proteins in rat brain by liquid chromatography and multiple-stage mass spectrometry. Itoh S, et al. Biochemistry, 2008 Sep 23. PMID 18729387
    2. Neurotrimin is an estrogen-regulated determinant of peripheral sympathetic innervation. Krizsan-Agbas D, et al. J Neurosci Res, 2008 Nov 1. PMID 18627025, Free PMC Article
    3. HEXIM2, a HEXIM1-related protein, regulates positive transcription elongation factor b through association with 7SK. Byers SA, et al. J Biol Chem, 2005 Apr 22. PMID 15713662
    4. Specificity of Hexim1 and Hexim2 complex formation with cyclin T1/T2, importin alpha and 7SK snRNA. Czudnochowski N, et al. J Mol Biol, 2010 Jan 8. PMID 19883659
    5. Next-generation sequencing to generate interactome datasets. Yu H, et al. Nat Methods, 2011 Jun. PMID 21516116, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 7SK snRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables snRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein HEXIM2
    Names
    MAQ1 paralog
    hexamethylene bis-acetamide inducible 2
    hexamthylene bis-acetamide inducible 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107054.2 → NP_001100524.1  protein HEXIM2

      See identical proteins and their annotated locations for NP_001100524.1

      Status: PROVISIONAL

      Source sequence(s)
      BC167046
      UniProtKB/TrEMBL
      A6HJQ2, B2RZ69, F6T841
      Related
      ENSRNOP00000052039.2, ENSRNOT00000004218.7
      Conserved Domains (2) summary
      PRK12705
      Location:180 → 283
      PRK12705; hypothetical protein; Provisional
      pfam15313
      Location:101 → 226
      HEXIM; Hexamethylene bis-acetamide-inducible protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      88572102..88584856
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247515.5 → XP_006247577.1  protein HEXIM2 isoform X1

      See identical proteins and their annotated locations for XP_006247577.1

      UniProtKB/TrEMBL
      A6HJQ2, B2RZ69, F6T841
      Conserved Domains (2) summary
      PRK12705
      Location:180 → 283
      PRK12705; hypothetical protein; Provisional
      pfam15313
      Location:101 → 226
      HEXIM; Hexamethylene bis-acetamide-inducible protein

    2. XM_006247514.5 → XP_006247576.1  protein HEXIM2 isoform X1

      See identical proteins and their annotated locations for XP_006247576.1

      UniProtKB/TrEMBL
      A6HJQ2, B2RZ69, F6T841
      Conserved Domains (2) summary
      PRK12705
      Location:180 → 283
      PRK12705; hypothetical protein; Provisional
      pfam15313
      Location:101 → 226
      HEXIM; Hexamethylene bis-acetamide-inducible protein

    3. XM_017597329.3 → XP_017452818.1  protein HEXIM2 isoform X1

      UniProtKB/TrEMBL
      A6HJQ2, B2RZ69, F6T841
      Conserved Domains (2) summary
      PRK12705
      Location:180 → 283
      PRK12705; hypothetical protein; Provisional
      pfam15313
      Location:101 → 226
      HEXIM; Hexamethylene bis-acetamide-inducible protein

    4. XM_006247518.5 → XP_006247580.1  protein HEXIM2 isoform X1

      See identical proteins and their annotated locations for XP_006247580.1

      UniProtKB/TrEMBL
      A6HJQ2, B2RZ69, F6T841
      Conserved Domains (2) summary
      PRK12705
      Location:180 → 283
      PRK12705; hypothetical protein; Provisional
      pfam15313
      Location:101 → 226
      HEXIM; Hexamethylene bis-acetamide-inducible protein

    5. XM_063269173.1 → XP_063125243.1  protein HEXIM2 isoform X1

      UniProtKB/TrEMBL
      A6HJQ2, B2RZ69, F6T841

    6. XM_006247516.5 → XP_006247578.1  protein HEXIM2 isoform X1

      See identical proteins and their annotated locations for XP_006247578.1

      UniProtKB/TrEMBL
      A6HJQ2, B2RZ69, F6T841
      Conserved Domains (2) summary
      PRK12705
      Location:180 → 283
      PRK12705; hypothetical protein; Provisional
      pfam15313
      Location:101 → 226
      HEXIM; Hexamethylene bis-acetamide-inducible protein

    7. XM_006247517.5 → XP_006247579.1  protein HEXIM2 isoform X1

      See identical proteins and their annotated locations for XP_006247579.1

      UniProtKB/TrEMBL
      A6HJQ2, B2RZ69, F6T841
      Conserved Domains (2) summary
      PRK12705
      Location:180 → 283
      PRK12705; hypothetical protein; Provisional
      pfam15313
      Location:101 → 226
      HEXIM; Hexamethylene bis-acetamide-inducible protein

    8. XM_008768289.4 → XP_008766511.1  protein HEXIM2 isoform X1

      See identical proteins and their annotated locations for XP_008766511.1

      UniProtKB/TrEMBL
      A6HJQ2, B2RZ69, F6T841
      Conserved Domains (2) summary
      PRK12705
      Location:180 → 283
      PRK12705; hypothetical protein; Provisional
      pfam15313
      Location:101 → 226
      HEXIM; Hexamethylene bis-acetamide-inducible protein

    9. XM_006247521.5 → XP_006247583.1  protein HEXIM2 isoform X1

      See identical proteins and their annotated locations for XP_006247583.1

      UniProtKB/TrEMBL
      A6HJQ2, B2RZ69, F6T841
      Conserved Domains (2) summary
      PRK12705
      Location:180 → 283
      PRK12705; hypothetical protein; Provisional
      pfam15313
      Location:101 → 226
      HEXIM; Hexamethylene bis-acetamide-inducible protein

    10. XM_063269172.1 → XP_063125242.1  protein HEXIM2 isoform X1

      UniProtKB/TrEMBL
      A6HJQ2, B2RZ69, F6T841

    11. XM_006247522.5 → XP_006247584.1  protein HEXIM2 isoform X1

      See identical proteins and their annotated locations for XP_006247584.1

      UniProtKB/TrEMBL
      A6HJQ2, B2RZ69, F6T841
      Conserved Domains (2) summary
      PRK12705
      Location:180 → 283
      PRK12705; hypothetical protein; Provisional
      pfam15313
      Location:101 → 226
      HEXIM; Hexamethylene bis-acetamide-inducible protein

    12. XM_006247520.5 → XP_006247582.1  protein HEXIM2 isoform X1

      See identical proteins and their annotated locations for XP_006247582.1

      UniProtKB/TrEMBL
      A6HJQ2, B2RZ69, F6T841
      Conserved Domains (2) summary
      PRK12705
      Location:180 → 283
      PRK12705; hypothetical protein; Provisional
      pfam15313
      Location:101 → 226
      HEXIM; Hexamethylene bis-acetamide-inducible protein
    Nucleotide Protein Strain
    Heading Accession and Version

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