cradd CASP2 and RIPK1 domain containing adaptor with death domain [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: craddprovided by ZNC
Official Full Name: CASP2 and RIPK1 domain containing adaptor with death domainprovided by ZNC
Primary source: ZFIN:ZDB-GENE-041010-168
See related: Ensembl:ENSDARG00000028192 AllianceGenome:ZFIN:ZDB-GENE-041010-168
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:101717
Summary: Predicted to enable death domain binding activity and protease binding activity. Predicted to act upstream of or within regulation of apoptotic process and signal transduction. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 34. Orthologous to human CRADD (CASP2 and RIPK1 domain containing adaptor with death domain). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 4

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (18383080..18416759, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (18394104..18427783, complement)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables death domain binding	IEA Inferred from Electronic Annotation more info
enables protease binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: death domain-containing protein CRADD

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001006066.1 → NP_001006066.1 death domain-containing protein CRADD

See identical proteins and their annotated locations for NP_001006066.1

Status: PROVISIONAL

Source sequence(s)

BC083256

UniProtKB/TrEMBL

B2GRV1, Q5RGW2, Q5XJP2

Related

ENSDARP00000038654.5, ENSDART00000033717.6

Conserved Domains (2) summary

cd08319
Location:117 → 199

Death_RAIDD; Death domain of RIP-associated ICH-1 homologous protein with a death domain

cd08327
Location:1 → 91

CARD_RAIDD; Caspase activation and recruitment domain of RIP-associated ICH-1 homologous protein with a death domain