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    rhogb ras homolog family member Gb [ Danio rerio (zebrafish) ]

    Gene ID: 336933, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rhogbprovided by ZNC
    Official Full Name
    ras homolog family member Gbprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-8877
    See related
    Ensembl:ENSDARG00000004301 AllianceGenome:ZFIN:ZDB-GENE-030131-8877
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ARHG; rhog; zgc:55848; wu:fk30f01
    Summary
    Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Acts upstream of or within response to bacterium. Predicted to be active in several cellular components, including cytoplasmic vesicle; cytoskeleton; and plasma membrane. Is expressed in dorsal aorta; macrophage; somite 3; and somite 4. Orthologous to human RHOG (ras homolog family member G). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See rhogb in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (30937693..30951883)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (30900998..30915188)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 6 member 7 Neighboring gene stromal interaction molecule 1b Neighboring gene uncharacterized LOC101886778 Neighboring gene post-GPI attachment to proteins 2 Neighboring gene nuclear cap binding subunit 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Promotion effect of liver tumor progression in male kras transgenic zebrafish induced by tris (1, 3-dichloro-2-propyl) phosphate. Chen S, et al. Ecotoxicol Environ Saf, 2020 Mar 15. PMID 31991394
    2. Progression of liver tumor was promoted by tris(1,3-dichloro-2-propyl) phosphate through the induction of inflammatory responses in kras(V12) transgenic zebrafish. Chen S, et al. Environ Pollut, 2019 Dec. PMID 31606661
    3. Rac2 Functions in Both Neutrophils and Macrophages To Mediate Motility and Host Defense in Larval Zebrafish. Rosowski EE, et al. J Immunol, 2016 Dec 15. PMID 27837107, Free PMC Article
    4. Microarray analysis of zebrafish cloche mutant using amplified cDNA and identification of potential downstream target genes. Qian F, et al. Dev Dyn, 2005 Jul. PMID 15937927
    5. Genomic annotation and expression analysis of the zebrafish Rho small GTPase family during development and bacterial infection. Salas-Vidal E, et al. Genomics, 2005 Jul. PMID 15894457

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rac protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cortical cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment or maintenance of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ras homolog family member Gb
    Names
    ras homolog gene family, member G (rho G)
    ras homolog gene family, member Gb
    rho G

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200040.2 → NP_956334.1  ras homolog family member Gb

      See identical proteins and their annotated locations for NP_956334.1

      Status: PROVISIONAL

      Source sequence(s)
      BC044508
      UniProtKB/TrEMBL
      B2GR44, Q803F2
      Related
      ENSDARP00000027635.6, ENSDART00000022562.7
      Conserved Domains (2) summary
      smart00174
      Location:6 → 179
      RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
      cl21455
      Location:1 → 191
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      30937693..30951883
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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