U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    lft1 lefty1 [ Danio rerio (zebrafish) ]

    Gene ID: 30145, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    lft1provided by ZNC
    Official Full Name
    lefty1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990630-10
    See related
    Ensembl:ENSDARG00000019920 AllianceGenome:ZFIN:ZDB-GENE-990630-10
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    atv; cb73; antivin; ik:tdsubc_2b12; xx:tdsubc_2b12
    Summary
    Predicted to enable cytokine activity. Acts upstream of or within determination of left/right symmetry; dorsal/ventral pattern formation; and embryonic heart tube development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including blastodisc; brain; germ ring; mesoderm; and tail bud. Human ortholog(s) of this gene implicated in congenital heart disease. Orthologous to several human genes including LEFTY2 (left-right determination factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See lft1 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (35073981..35076377, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (35171102..35173498, complement)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488670 Neighboring gene kinesin family member 26Bb Neighboring gene heterogeneous nuclear ribonucleoprotein Ub Neighboring gene CDC42 binding protein kinase alpha (DMPK-like) b Neighboring gene F-box protein 16 Neighboring gene frizzled class receptor 3a

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The lefty-related factor Xatv acts as a feedback inhibitor of nodal signaling in mesoderm induction and L-R axis development in xenopus. Cheng AM, et al. Development, 2000 Mar. PMID 10662644
    2. Zebrafish and medaka: model organisms for a comparative developmental approach of brain asymmetry. Signore IA, et al. Philos Trans R Soc Lond B Biol Sci, 2009 Apr 12. PMID 19064351, Free PMC Article
    3. Lefty antagonism of Squint is essential for normal gastrulation. Feldman B, et al. Curr Biol, 2002 Dec 23. PMID 12498688
    4. Novel mix-family homeobox genes in zebrafish and their differential regulation. Hirata T, et al. Biochem Biophys Res Commun, 2000 May 19. PMID 10814508
    5. Cooperative roles of Bozozok/Dharma and Nodal-related proteins in the formation of the dorsal organizer in zebrafish. Shimizu T, et al. Mech Dev, 2000 Mar 1. PMID 10704853

    See all (195) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Zebrafish Cdx1b modulates epithalamic asymmetry by regulating ndr2 and lft1 expression.
      Title: Zebrafish Cdx1b modulates epithalamic asymmetry by regulating ndr2 and lft1 expression.
    2. Theauthors find that zebrafish lefty mutants exhibit excess Nodal signaling and increased specification of mesendoderm, resulting in embryonic lethality.
      Title: Nodal patterning without Lefty inhibitory feedback is functional but fragile.
    3. Our data do not support the reaction-diffusion model, but instead, we propose that Nodal activates signaling in a temporal window that is defined by a miR-430-mediated delay of Lft1/2 translation
      Title: A Temporal Window for Signal Activation Dictates the Dimensions of a Nodal Signaling Domain.
    4. results indicate that differential diffusivity is the major determinant of the differences in Nodal/Lefty range and provide biophysical support for reaction-diffusion models of activator/inhibitor-mediated patterning
      Title: Differential diffusivity of Nodal and Lefty underlies a reaction-diffusion patterning system.
    5. both Nodal and Bmp independently are required for lefty1 expression to assure unilateral Nodal activation and correct LR patterning
      Title: Bmp and nodal independently regulate lefty1 expression to maintain unilateral nodal activity during left-right axis specification in zebrafish.
    6. Bmp represses Nodal signaling independently of lefty1 expression and through the activity of a ligand other than Bmp4.
      Title: Two additional midline barriers function with midline lefty1 expression to maintain asymmetric Nodal signaling during left-right axis specification in zebrafish.
    7. study reports that microRNA-430 (miR-430) dampens and balances the expression of the transforming growth factor-beta (TGF-beta) Nodal agonist squint and the TGF-beta Nodal antagonist lefty
      Title: Target protectors reveal dampening and balancing of Nodal agonist and antagonist by miR-430.
    8. we find that Cyclops is specifically required for the maintenance of lefty1 and lefty2 transcription
      Title: Lefty antagonism of Squint is essential for normal gastrulation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transforming growth factor beta receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anterior/posterior axis specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within determination of heart left/right asymmetry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within determination of left/right asymmetry in diencephalon IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within determination of left/right asymmetry in lateral mesoderm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within determination of left/right symmetry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within dorsal/ventral pattern formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within embryonic heart tube development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mesoderm development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    lefty1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_130960.1 → NP_571035.1  lefty1 precursor

      See identical proteins and their annotated locations for NP_571035.1

      Status: PROVISIONAL

      Source sequence(s)
      AF172089
      UniProtKB/TrEMBL
      Q9PW55
      Related
      ENSDARP00000005312.5, ENSDART00000019196.7
      Conserved Domains (2) summary
      pfam00688
      Location:24 → 192
      TGFb_propeptide; TGF-beta propeptide
      cd13758
      Location:265 → 350
      TGF_beta_LEFTY1_2; transforming growth factor beta (TGF-beta) like domain found in left-right determination factor 1 (lefty-1), factor 2 (lefty-2) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      35073981..35076377 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous