hsd17b8 hydroxysteroid (17-beta) dehydrogenase 8 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hsd17b8provided by ZNC
Official Full Name: hydroxysteroid (17-beta) dehydrogenase 8provided by ZNC
Primary source: ZFIN:ZDB-GENE-010110-1
See related: Ensembl:ENSDARG00000001169 AllianceGenome:ZFIN:ZDB-GENE-010110-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: KE6; fabgl; zgc:112550; si:dz12f11.4
Summary: Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to act upstream of or within fatty acid metabolic process. Orthologous to human HSD17B8 (hydroxysteroid 17-beta dehydrogenase 8). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (7173871..7179691)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (7254946..7260766)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IBA Inferred from Biological aspect of Ancestor more info
enables quinone binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: (3R)-3-hydroxyacyl-CoA dehydrogenase

Names: FabG (beta-ketoacyl-[acyl-carrier-protein] reductase, E. coli) like

NP_001005292.2

EC 1.1.1.62

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005292.2 → NP_001005292.2 (3R)-3-hydroxyacyl-CoA dehydrogenase

See identical proteins and their annotated locations for NP_001005292.2

Status: PROVISIONAL

Source sequence(s)

BC093373

UniProtKB/TrEMBL

Q561S1

Related

ENSDARP00000001459.9, ENSDART00000001331.10

Conserved Domains (2) summary

cd05333
Location:10 → 254

BKR_SDR_c; beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs

PRK05653
Location:13 → 254

fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Validated