ahr2 aryl hydrocarbon receptor 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ahr2provided by ZNC
Official Full Name: aryl hydrocarbon receptor 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-990714-16
See related: Ensembl:ENSDARG00000021833 AllianceGenome:ZFIN:ZDB-GENE-990714-16
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ahrb
Summary: Enables nuclear receptor activity and sequence-specific DNA binding activity. Contributes to DNA binding activity. Acts upstream of or within several processes, including fin development; ovarian follicle development; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including blood vessel; fin; mandibular arch skeleton; nervous system; and pleuroperitoneal region. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 22

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (13046270..13164730, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (13021493..13139953, complement)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Findings suggest that ahr1 genes do not have overlapping functions with ahr2 in fin and craniofacial development or TCDD-dependent toxicity, and that estrogen receptors are not constitutive partners of ahr2.
Title: ahr2, But Not ahr1a or ahr1b, Is Required for Craniofacial and Fin Development and TCDD-dependent Cardiotoxicity in Zebrafish.
Data suggest AHR2 is required for the proper development of some aspect(s) of the neuromuscular and/or sensory system, with impaired behavioral responses observed in larval and adult AHR2-null zebrafish.
Title: AHR2 required for normal behavioral responses and proper development of the skeletal and reproductive systems in zebrafish.
A long noncoding RNA (referred to as slincR) is expressed during development and is regulated by AHR2.
Title: In Vivo Characterization of an AHR-Dependent Long Noncoding RNA Required for Proper Sox9b Expression.
A functioning CYP1/AHR2 feedback loop is crucial for regulation of AHR2 signaling by a potential physiological ligand in vivo.
Title: Biological effects of 6-formylindolo[3,2-b]carbazole (FICZ) in vivo are enhanced by loss of CYP1A function in an Ahr2-dependent manner.
Selected zebrafish CYP1, CYP2 and CYP3 genes appear to be under the regulation of both pregnane X receptor and aryl hydrocarbon receptor 2.
Title: Role of pregnane X receptor and aryl hydrocarbon receptor in transcriptional regulation of pxr, CYP2, and CYP3 genes in developing zebrafish.
The effects of weak aryl hydrocarbon receptor agonists on zebrafish embryo heart development after inhibition of CYP1a and AHR2 knockdown are reported.
Title: Zebrafish cardiotoxicity: the effects of CYP1A inhibition and AHR2 knockdown following exposure to weak aryl hydrocarbon receptor agonists.
the toxic effect of Paclobutrazol on digestive organs is mediated by AhR2
Title: Aryl hydrocarbon receptor 2 mediates the toxicity of Paclobutrazol on the digestive system of zebrafish embryos.
AHR/AHR2-mediated transcription is likely a common regulatory mechanism for teleost CYP3A65 genes in zebrafish.
Title: Regulation of zebrafish CYP3A65 transcription by AHR2.
Site directed mutagenesis facilitated comparative structure-function analysis of ahr1a and ahr2 of Danio rerio, revealing the importance of specific binding site residues.
Title: Comparative analysis of homology models of the AH receptor ligand binding domain: verification of structure-function predictions by site-directed mutagenesis of a nonfunctional receptor.
These results provide in vivo proof-of-principle results demonstrating the effectiveness of dominant negative aryl hydrocarbon receptor (AHR) in manipulating AHR activity in vivo.
Title: A dominant negative zebrafish Ahr2 partially protects developing zebrafish from dioxin toxicity.

Submit: New GeneRIF Correction See all GeneRIFs (18)

General gene information

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Markers

fk20c12.y1 (e-PCR)
- UniSTS:200632

fc89a08.x1 (e-PCR)
- UniSTS:194752

G46920 (e-PCR)
- UniSTS:107715

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
contributes_to DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables ligand-activated transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription cis-regulatory region binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to organic cyclic compound	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cellular response to organic cyclic compound	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to xenobiotic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cranial skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fin development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organismal reproductive process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ovarian follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IPI Inferred from Physical Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to toxic substance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to xenobiotic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to xenobiotic stimulus	IPI Inferred from Physical Interaction more info	PubMed
acts_upstream_of_or_within rhythmic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within xenobiotic metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of aryl hydrocarbon receptor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: aryl hydrocarbon receptor 2

Names: AHR1b; aryl hydrocarbon receptor b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131264.1 → NP_571339.1 aryl hydrocarbon receptor 2

See identical proteins and their annotated locations for NP_571339.1

Status: PROVISIONAL

Source sequence(s)

AF063446

UniProtKB/TrEMBL

Q9YGV3

Related

ENSDARP00000096540.3, ENSDART00000105762.4

Conserved Domains (5) summary

smart00091
Location:120 → 183

PAS; PAS domain

cd00083
Location:35 → 76

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

cd00130
Location:305 → 385

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam00989
Location:118 → 232

PAS; PAS fold

pfam14598
Location:292 → 396

PAS_11; PAS domain