wdr18 WD repeat domain 18 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: wdr18provided by ZNC
Official Full Name: WD repeat domain 18provided by ZNC
Primary source: ZFIN:ZDB-GENE-040905-4
See related: Ensembl:ENSDARG00000041113 AllianceGenome:ZFIN:ZDB-GENE-040905-4
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:92370; wu:fa16f06; wu:fb79d07
Summary: Involved in Kupffer's vesicle development and determination of left/right symmetry. Predicted to be located in dynein axonemal particle. Predicted to be part of nuclear pre-replicative complex and rixosome complex. Is expressed in Kupffer's vesicle; forerunner cell group; liver; and pancreas. Orthologous to human WDR18 (WD repeat domain 18). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 11

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (13642178..13789451)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (13584519..13731792)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The identification and functional analyses of zebrafish wdr18, a novel gene that encodes a WD-repeat protein that is highly conserved among vertebrate species, is reported.
Title: Wdr18 is required for Kupffer's vesicle formation and regulation of body asymmetry in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

fi54a08.y1 (e-PCR)
- UniSTS:197699

fb79d07.x1 (e-PCR)
- UniSTS:191481

fb79d07.x1 (e-PCR)
- UniSTS:191482

Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
involved_in DNA-templated DNA replication	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Kupffer's vesicle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Kupffer's vesicle development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of left/right symmetry	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rRNA processing	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in dynein axonemal particle	ISS Inferred from Sequence or Structural Similarity more info
part_of nuclear pre-replicative complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of rixosome complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: WD repeat-containing protein 18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005206.1 → NP_001005206.1 WD repeat-containing protein 18

See identical proteins and their annotated locations for NP_001005206.1

Status: PROVISIONAL

Source sequence(s)

BC080252

UniProtKB/Swiss-Prot

Q68EI0

UniProtKB/TrEMBL

B2GT94

Related

ENSDARP00000060250.3, ENSDART00000060251.4

Conserved Domains (4) summary

COG2319
Location:6 → 320

WD40; WD40 repeat [General function prediction only]

pfam14077
Location:383 → 430

WD40_alt; Alternative WD40 repeat motif

sd00039
Location:84 → 119

7WD40; WD40 repeat [structural motif]

cl02567
Location:80 → 320

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...