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    agps alkylglycerone phosphate synthase [ Danio rerio (zebrafish) ]

    Gene ID: 386801, updated on 9-Dec-2024

    Summary

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    Official Symbol
    agpsprovided by ZNC
    Official Full Name
    alkylglycerone phosphate synthaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-031118-14
    See related
    Ensembl:ENSDARG00000042821 AllianceGenome:ZFIN:ZDB-GENE-031118-14
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fd16e06; zgc:56718; wu:fd16e06
    Summary
    Predicted to enable alkylglycerone-phosphate synthase activity. Predicted to be involved in lipid biosynthetic process. Predicted to act upstream of or within lipid metabolic process. Predicted to be active in peroxisome. Human ortholog(s) of this gene implicated in rhizomelic chondrodysplasia punctata and rhizomelic chondrodysplasia punctata type 3. Orthologous to human AGPS (alkylglycerone phosphate synthase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See agps in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (1589672..1639965, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (1587384..1637817, complement)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene si:ch211-222f23.6 Neighboring gene phosphodiesterase 11a Neighboring gene uncharacterized LOC137496439 Neighboring gene microRNA 148 Neighboring gene nfe2 like bZIP transcription factor 2a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Developmental roles of D-bifunctional protein-A zebrafish model of peroxisome dysfunction. Kim YI, et al. Mol Cells, 2014 Jan. PMID 24552713, Free PMC Article
    2. Slc25a17 acts as a peroxisomal coenzyme A transporter and regulates multiorgan development in zebrafish. Kim YI, et al. J Cell Physiol, 2020 Jan. PMID 31187491
    3. Insights Into the Peroxisomal Protein Inventory of Zebrafish. Kamoshita M, et al. Front Physiol, 2022. PMID 35295584, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alkylglycerone-phosphate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alkylglycerone-phosphate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ether lipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alkyldihydroxyacetonephosphate synthase, peroxisomal
    NP_956407.1
    XP_068079442.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200113.1 → NP_956407.1  alkyldihydroxyacetonephosphate synthase, peroxisomal

      See identical proteins and their annotated locations for NP_956407.1

      Status: PROVISIONAL

      Source sequence(s)
      BC045516
      UniProtKB/TrEMBL
      A0A8M9PRZ0, Q7ZVJ9
      Related
      ENSDARP00000062849.4, ENSDART00000062850.6
      Conserved Domains (3) summary
      COG0277
      Location:175 → 623
      GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
      pfam01565
      Location:177 → 318
      FAD_binding_4; FAD binding domain
      pfam02913
      Location:355 → 628
      FAD-oxidase_C; FAD linked oxidases, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      1589672..1639965 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068223341.1 → XP_068079442.1  alkyldihydroxyacetonephosphate synthase, peroxisomal isoform X1

      UniProtKB/TrEMBL
      A0A8M9PRZ0
    Nucleotide Protein Strain
    Heading Accession and Version

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