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    tbc1d14 TBC1 domain family, member 14 [ Danio rerio (zebrafish) ]

    Gene ID: 557744, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tbc1d14provided by ZNC
    Official Full Name
    TBC1 domain family, member 14provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6136
    See related
    Ensembl:ENSDARG00000003520 AllianceGenome:ZFIN:ZDB-GENE-030131-6136
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sb:eu1004; wu:fi35h01; wu:fi42a03; si:dkey-120m5.1
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in regulation of autophagosome assembly. Predicted to be active in autophagosome and recycling endosome. Orthologous to human TBC1D14 (TBC1 domain family member 14). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See tbc1d14 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (39680106..39705766)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (39408885..39432125)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase non-receptor type 5 Neighboring gene KIAA0232 Neighboring gene chemokine (C-C motif) ligand 36, duplicate 1 Neighboring gene si:dkey-58i8.5 Neighboring gene serine/threonine-protein kinase pim-3-like Neighboring gene cilia and flagella associated protein 184

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolution and expression of the phosphodiesterase 6 genes unveils vertebrate novelty to control photosensitivity. Lagman D, et al. BMC Evol Biol, 2016 Jun 13. PMID 27296292, Free PMC Article
    2. Characterization of the Apelin/Elabela Receptors (APLNR) in Chickens, Turtles, and Zebrafish: Identification of a Novel Apelin-Specific Receptor in Teleosts. Zhang J, et al. Front Endocrinol (Lausanne), 2018. PMID 30631305, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0608

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in autophagosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    TBC1 domain family member 14

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      39680106..39705766
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005166439.5 → XP_005166496.1  TBC1 domain family member 14 isoform X1

      See identical proteins and their annotated locations for XP_005166496.1

      UniProtKB/TrEMBL
      A0A8N7TAE1, F6P7J8
      Conserved Domains (2) summary
      COG5210
      Location:293 → 656
      COG5210; GTPase-activating protein [General function prediction only]
      pfam00566
      Location:485 → 651
      RabGAP-TBC; Rab-GTPase-TBC domain

    2. XM_678089.9 → XP_683181.1  TBC1 domain family member 14 isoform X1

      See identical proteins and their annotated locations for XP_683181.1

      UniProtKB/TrEMBL
      A0A8N7TAE1, F6P7J8
      Related
      ENSDARP00000121985.1, ENSDART00000133420.4
      Conserved Domains (2) summary
      COG5210
      Location:293 → 656
      COG5210; GTPase-activating protein [General function prediction only]
      pfam00566
      Location:485 → 651
      RabGAP-TBC; Rab-GTPase-TBC domain

    3. XM_005166440.5 → XP_005166497.1  TBC1 domain family member 14 isoform X2

      UniProtKB/TrEMBL
      A0A8M2BE06
      Related
      ENSDARP00000040945.8, ENSDART00000040946.9
      Conserved Domains (1) summary
      pfam00566
      Location:186 → 352
      RabGAP-TBC; Rab-GTPase-TBC domain
    Nucleotide Protein Strain
    Heading Accession and Version

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